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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제23권 제1호
- 발행연도
- 2019.1
- 수록면
- 34 - 37 (4page)
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초록· 키워드
오류제보하기
Gadolinium contrast agents (CAs) are integral components of clinical magnetic resonance imaging (MRI). However, safety concerns have arisen regarding the use of gadolinium CAs, due to their association with nephrogenic systemic fibrosis (NSF). Furthermore, recently the long-term retention of Gd3+-based CAs in brains patients with normal renal function raised another possible safety issue. The safety concerns of Gd3+-based CAs have been based on the ligand structure of Gd3+-based CAs, and findings that Gd3+-based CAs with linear ligand structures showed much higher incidences of NSF and brain retention of CAs than Gd3+-based CAs with macrocyclic ligand structure. In the current study, we report the in vivo biodistribution profile of a new highly stable multifunctional Gd3+-based CA, with macrocyclic ligand structure (HNP-2006). MR imaging using HNP-2006 demonstrated a significant contrast enhancement in many different organs. Furthermore, the contrast enhanced tumor imaging using HNP-2006 confirmed that this new macrocyclic CA can be used for detecting tumor in the central nervous system. Therefore, this new multifunctional HNP-2006 with macrocyclic ligand structure shows great promise for whole-body clinical application.
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등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Geraldes CF / 2009 / Classification and basic properties of contrast agents for magnetic resonance imaging / Contrast Media Mol Imaging 4:1~23
Grobner T / 2006 / Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? / Nephrol Dial Transplant 21:1104~1108
Marckmann P / 2006 / Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging / J Am Soc Nephrol 17:2359~2362
Kanda T / 2015 / Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy / Radiology 276:228~232
Broome DR / 2008 / Nephrogenic systemic fibrosis associated with gadolinium based contrast agents: a summary of the medical literature reporting / Eur J Radiol 66:230~234
Grobner T / 2006 / Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? / Nephrol Dial Transplant 21:1104~1108
Marckmann P / 2006 / Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging / J Am Soc Nephrol 17:2359~2362
Kanda T / 2015 / Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy / Radiology 276:228~232
Broome DR / 2008 / Nephrogenic systemic fibrosis associated with gadolinium based contrast agents: a summary of the medical literature reporting / Eur J Radiol 66:230~234
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