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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 97 - 103 (7page)
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초록· 키워드
오류제보하기
Androgens act in almost all tissues throughout the lifetime and have important roles in skeletal muscles. The levels of androgens increase during puberty and remain sustained at high levels in adulthood. Because androgens have an anabolic effect on skeletal muscles and muscle stem cells, these increased levels of androgens after puberty should lead to spontaneous muscle hypertrophy and hyperplasia in adulthood. However, the maintenance of muscle volume, myonuclei number per myofiber, and quiescent state of satellite cells in adulthood despite the high levels of androgens produces paradoxical outcomes. Our recent study revealed that the physiological increase of androgens at puberty initiates the transition of muscle stem cells from proliferation to quiescence by the androgen-Mindbomb1-Notch signaling axis. This newly discovered androgen action on skeletal muscles underscores the physiological importance of androgens on muscle homeostasis throughout life. This review will provide an overview of the new androgen action on skeletal muscles and discuss the paradoxical effects of androgens suggested in previous studies.
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등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Allen, R. E. / 1979 / Cellular aspects of muscle growth : myogenic cell proliferation / J. Anim. Sci 49:115~127
John F. Bachman / 2018 / Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution / Development 145(20):dev167197
Basualto-Alarcon, C. / 2014 / Sarcopenia and androgens : a link between pathology and treatment / Front. Endocrinol 5:217
Bhasin, S. / 2003 / Testosterone supplementation for aging-associated sarcopenia / J. Gerontol. A Biol. Sci. Med. Sci 58:1002~1008
Bhasin, S. / 1996 / The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men / N. Engl. J. Med 335:1~7
John F. Bachman / 2018 / Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution / Development 145(20):dev167197
Basualto-Alarcon, C. / 2014 / Sarcopenia and androgens : a link between pathology and treatment / Front. Endocrinol 5:217
Bhasin, S. / 2003 / Testosterone supplementation for aging-associated sarcopenia / J. Gerontol. A Biol. Sci. Med. Sci 58:1002~1008
Bhasin, S. / 1996 / The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men / N. Engl. J. Med 335:1~7
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