지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제3호
- 발행연도
- 2019.1
- 수록면
- 432 - 437 (6page)
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초록· 키워드
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Objective: The aims of this study were to investigate the effects of daily low-dose tadalafil on cognitive function and to examine whether there was a change in cerebral blood flow (CBF) in patients with erectile dysfunction (ED) and mild cognitive impairment. Methods: Male patients aged 50 to 75 years with at least three months of ED (International Index of Erectile Function [IIEF]-5 score ≤ 21) and mild cognitive impairment (Montreal Cognitive Assessment [MoCA] score ≤ 22) were included in the study. The subjects were prescribed a low-dose PDE5 inhibitor (tadalafil 5 mg) to be taken once daily for eight weeks. Changes in MoCA score and single-photon emission computed tomography (SPECT) study between the two time-points were assessed by paired t tests. Results: Overall, 30 male patients were assigned to the treatment group in this study and 25 patients completed the eight-week treatment course. Five patients were withdrawn due to adverse events such as myalgia and dizziness. Mean baseline IIEF and MoCA scores were 7.52 ± 4.84 and 18.92 ± 1.78. After the eight-week treatment, mean IIEF and MoCA scores were increased to 12.92 ± 7.27 (p ＜ 0.05) and 21.8 ± 1.71 (p ＜ 0.05), respectively. Patients showed increased relative regional CBF in the postcentral gyrus, precuneus, and brainstem after tadalafil administration versus at baseline (p ＜ 0.001). Conclusion: The results of this prospective clinical study suggest that daily use of tadalafil 5 m
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Reneerkens OA / 2012 / Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms / Neurobiol Learn Mem 97:370~379
Bertsch K / 2009 / Resting cerebral blood flow, attention, and aging / Brain Res 1267:77~88
Kurt M / 2004 / Effect of sildenafil on anxiety in the plus-maze test in mice / Pol J Pharmacol 56:353~357
Milman HA / 2002 / Neurologic, psychological, and aggressive disturbances with sildenafil / Ann Pharmacother 36:1129~1134
Reneerkens OA / 2009 / Selective phosphodiesterase inhibitors: a promising target for cognition enhancement / Psychopharmacology (Berl) 202:419~443
Bertsch K / 2009 / Resting cerebral blood flow, attention, and aging / Brain Res 1267:77~88
Kurt M / 2004 / Effect of sildenafil on anxiety in the plus-maze test in mice / Pol J Pharmacol 56:353~357
Milman HA / 2002 / Neurologic, psychological, and aggressive disturbances with sildenafil / Ann Pharmacother 36:1129~1134
Reneerkens OA / 2009 / Selective phosphodiesterase inhibitors: a promising target for cognition enhancement / Psychopharmacology (Berl) 202:419~443
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