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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 161 - 165 (5page)
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초록· 키워드
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Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and has high rates of metastasis. Transforming growth factor beta-inducible protein (TGFBI) is an extracellular matrix component involved in tumour growth and metastasis. However, the exact role of TGFBI in NSCLC remains controversial. Gene silencing via DNA methylation of the promoter region is common in lung tumorigenesis and could thus be used for the development of molecular biomarkers. We analysed the methylation status of the TGFBI promoter in 138 NSCLC specimens via methylation-specific PCR and evaluated the correlation between TGFBI methylation and patient survival. TGFBI promoter methylation was detected in 25 (18.1%) of the tumours and was demonstrated to be associated with gene silencing. We observed no statistical correlation between TGFBI methylation and clinicopathological characteristics. Univariate and multivariate analyses showed that TGFBI methylation is significantly associated with poor survival outcomes in adenocarcinoma cases (adjusted hazard ratio = 2.88, 95% confidence interval = 1.19–6.99, P = 0.019), but not in squamous cell cases. Our findings suggest that methylation in the TGFBI promoter may be associated with pathogenesis of NSCLC and can be used as a predictive marker for lung adenocarcinoma prognosis. Further large-scale studies are needed to confirm these findings.
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참고문헌 (24)
참고문헌 신청
Choi, J. E. / 2008 / Aberrant methyaltion of ADAMTS1 in non-small cell lung cancer / Cancer Genet 187:80~84
Fang, H. / 2014 / Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias / Chin. Med. J 127:1645~1650
Irigoyen, M. / 2010 / TGFBI expression is associated with a better response to chemotherapy in NSCLC / Mol. Cancer 9:130~141
Kang, S. / 2010 / Frequent promoter hypermethylation of TGFBI in epithelial ovarian cancer / Gynecol. Oncol 118:58~63
Kim, D. S. / 2007 / Aberrant methyaltion of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinocopathologic features / Cancer 110:2789~2792
Fang, H. / 2014 / Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias / Chin. Med. J 127:1645~1650
Irigoyen, M. / 2010 / TGFBI expression is associated with a better response to chemotherapy in NSCLC / Mol. Cancer 9:130~141
Kang, S. / 2010 / Frequent promoter hypermethylation of TGFBI in epithelial ovarian cancer / Gynecol. Oncol 118:58~63
Kim, D. S. / 2007 / Aberrant methyaltion of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinocopathologic features / Cancer 110:2789~2792
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