지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 263 - 273 (11page)
이용수
초록· 키워드
오류제보하기
Background Procalcitonin (PCT) is a diagnostic biomarker for bacterial infections in critically-ill patients. However, the cut-off value of PCT for the diagnosis of bacterial infections is unclear and unreliable. This study aimed to determine the optimal cut-off value of PCT for the diagnosis of bacterial infections in critically-ill patients. Materials and Methods We conducted a retrospective study involving 311 adult patients who had been admitted to the medical or surgical intensive care unit for more than 24 hours from 2013 to 2015. At least one blood test for PCT level was performed for all patients within the first 24 hours of suspecting an infection. Results One hundred and fifty-seven patients had bacterial infections, while 154 did not. Patients with bacterial infections had a significantly higher median PCT level than those without bacterial infections (1.90 ng/mL vs. 0.16 ng/mL, P <0.001). The area under the receiver operating characteristic curve of PCT for discriminating between bacterial and non-bacterial infections was 0.874 (95% confidence interval: 0.834, 0.914; P <0.001). The optimal cut-off value of PCT for differentiating between fevers due to bacterial infections from those due to non-bacterial infections was 0.5 ng/mL, with a sensitivity of 84.7%, specificity of 79.9%, positive predictive value of 81.1%, and negative predictive value of 83.7%. Conclusion PCT was found to be an accurate biomarker for the diagnosis of bacterial infections among patients admitted to medical and surgical intensive care units. The optimal cut-off value of PCT for the diagnosis of bacterial infections was 0.5 ng/mL.
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참고문헌 (35)
참고문헌 신청
Barati M / 2008 / Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases / Burns 34:770~774
Laupland KB / 2009 / Fever in the critically ill medical patient / Crit Care Med 37(Suppl 7):S273~S278
Levin PD / 2012 / Antimicrobial use in the ICU : indications and accuracy--an observational trial / J Hosp Med 7:672~678
Huttner A / 2013 / Antimicrobial resistance : a global view from the 2013 World Healthcare-Associated Infections Forum / Antimicrob Resist Infect Control 2:31
Pittet D / 1995 / Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients / Intensive Care Med 21:302~309
Laupland KB / 2009 / Fever in the critically ill medical patient / Crit Care Med 37(Suppl 7):S273~S278
Levin PD / 2012 / Antimicrobial use in the ICU : indications and accuracy--an observational trial / J Hosp Med 7:672~678
Huttner A / 2013 / Antimicrobial resistance : a global view from the 2013 World Healthcare-Associated Infections Forum / Antimicrob Resist Infect Control 2:31
Pittet D / 1995 / Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients / Intensive Care Med 21:302~309
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