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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제5호
- 발행연도
- 2019.1
- 수록면
- 519 - 526 (8page)
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초록· 키워드
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To date, hyperthermia and chemotherapy have been widely investigated in the field of anticancer nanomedicine. However, in many cases, the efficacy of monotherapies have been limited owing to the heterogeneity of cancers and the acquired drug resistance. Noteworthy, hyperthermia has been demonstrated to offer numerous advantages when integrated with chemotherapy in nanoplatforms, namely increased accumulation of drugs in tumor site, enhanced cellular uptake, inhibition of DNA repair, and accelerated drug cytotoxicity against cancer cells. These evidences suggest a promising anticancer synergistic effect of hyperthermia and chemotherapy. This review will discuss the underlying mechanisms of action of chemohyperthermia combination therapy, and especially the strategies of design of advanced nanocarriers to effectively co-deliver hyperthermia and chemotherapeutic agents to the tumor based on various types of materials.
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참고문헌 (52)
참고문헌 신청
Bai J / 2014 / Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy / Biomaterials 35:5805~5813
Chen R / 2013 / Combined near-IR photothermal therapy and chemotherapy using goldnanorod/chitosan hybrid nanospheres to enhance the antitumor effect / Biomater Sci 1:285~293
Chen H / 2015 / Combined chemo-and photo-thermal therapy delivered by multifunctional theranostic gold nanorod-loaded microcapsules / Nanoscale 7:8884~8897
Chen Y / 2016 / Polydopamine-based coordination nanocomplex for T 1/T 2 dual mode magnetic resonance imaging-guided chemo-photothermal synergistic therapy / Biomaterials 77:198~206
Cheng L / 2014 / Functional nanomaterials for phototherapies of cancer / Chem Rev 114:10869~10939
Chen R / 2013 / Combined near-IR photothermal therapy and chemotherapy using goldnanorod/chitosan hybrid nanospheres to enhance the antitumor effect / Biomater Sci 1:285~293
Chen H / 2015 / Combined chemo-and photo-thermal therapy delivered by multifunctional theranostic gold nanorod-loaded microcapsules / Nanoscale 7:8884~8897
Chen Y / 2016 / Polydopamine-based coordination nanocomplex for T 1/T 2 dual mode magnetic resonance imaging-guided chemo-photothermal synergistic therapy / Biomaterials 77:198~206
Cheng L / 2014 / Functional nanomaterials for phototherapies of cancer / Chem Rev 114:10869~10939
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