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자료유형
학술저널
저자정보
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제33권 제2호
발행연도
2019.1
수록면
142 - 149 (8page)

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Purpose: To determine the origin of epiretinal proliferation (EP), a condition that is occasionally observed inlamellar hole and macular hole cases, and EP outcomes after vitrectomy. Methods: This is a retrospective observational case review of 17 eyes with EP that underwent vitrectomy, EPdissection, and internal limiting membrane peeling between January 2013 and December 2016. Surgical specimensof EP tissue were successfully obtained from 5 cases and they were analyzed after immunohistochemicalstaining. Postoperative outcomes, including best-corrected visual acuity (BCVA) and macular configurationin spectral domain-optical coherence tomography, were reviewed. Results: Mean BCVA improved from 0.54 ± 0.36 logarithms of the minimum angle of resolution preoperativelyto 0.32 ± 0.38 logarithms of the minimum angle of resolution postoperatively (p = 0.002). BCVA improvedin 13 eyes and remained unchanged in four eyes. No cases experienced vision decline after surgery. All 17patients’ lamellar hole or macular hole were successfully closed. Despite hole closure, ellipsoid zone defectswere not corrected in 11 of the 17 patients. In immunohistochemical analyses, anti-glial fibrillary acidic proteinand pan-keratin (AE1/AE3) were positive, but synaptophysin, anti-α-smooth muscle actin, and anti-CD68 werenegative. Conclusions: The epiretinal proliferative membrane seems to originate from Müller cells, not from the vitreous. Itis unclear whether retinal pigment epithelia also contribute to EP formation. Gentle handling and preservationof the epiretinal proliferative tissue is crucial for successful surgical outcomes.

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