지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 464 - 469 (6page)
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초록· 키워드
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Background: Negative urine cultures to rule out urinary tract infections (UTI) generate a considerable laboratory workload; thus, a rapid screening test is desirable. We evaluated the performance of a new automated microscopy analyzer, cobas u 701 (Roche Diagnostics International, Rotkreuz, Switzerland) for the screening of UTI, and developed a rule-out strategy to reduce the number of samples requiring culture. We also assessed squamous epithelial cell (SEC) count as a predictor of culture contamination. Methods: In total, 1,604 urine samples from outpatients were analyzed with cobas u 701 and culture. Bacterial (BAC) and white blood cell (WBC) counts were used for sample interpretation. To determine a useful cut-off point to predict negative cultures, we selected the highest sensitivity and specificity values obtained from ROC curves. Diagnostic accuracy by age and gender was evaluated. Results: Urine culture showed growth of ≥104 colony forming units (CFU)/mL in 256 samples (16.0%). The highest sensitivity (91.8%) and specificity (68.4%) were obtained for cut-off points of 119 BAC/μL and 22 WBC/μL. The combination of BAC and WBC improved the performance of the rule-out strategy with a low rate of false-negative results (1.5%) and a high negative predictive value (NPV, 97.3%). Fifty-seven percent of the samples would not have required culture. SEC count was a poor predictor of culture contamination. Conclusions: cobas u 701 can substantially reduce the number of urine samples requiring culture, with a low false-negative rate and a high NPV.
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참고문헌 (20)
참고문헌 신청
Stalenhoef JE / 2015 / Febrile urinary tract infection in the emergency room / Curr Opin Infect Dis 28:106~111
Okada H / 2000 / Detection of significant bacteriuria by automated urinalysis using flow cytometry / J Clin Microbiol 38:2870~2872
Tessari A / 2015 / Screening of presumptive urinary tract infections by the automated urine sediment analyser sediMAX / Clin Chem Lab Med 53(S2):s1503~s1508
Brilha S / 2010 / Use of flow cytometry(Sysmex UF-100)to screen for positive urine cultures : in search for the ideal cut-off / Clin Chem Lab Med 48:289~292
Evans R / 2006 / Testing by Sysmex UF-100 flow cytometer and with bacterial culture in a diagnostic laboratory : a comparison / J Clin Pathol 59:661~662
Okada H / 2000 / Detection of significant bacteriuria by automated urinalysis using flow cytometry / J Clin Microbiol 38:2870~2872
Tessari A / 2015 / Screening of presumptive urinary tract infections by the automated urine sediment analyser sediMAX / Clin Chem Lab Med 53(S2):s1503~s1508
Brilha S / 2010 / Use of flow cytometry(Sysmex UF-100)to screen for positive urine cultures : in search for the ideal cut-off / Clin Chem Lab Med 48:289~292
Evans R / 2006 / Testing by Sysmex UF-100 flow cytometer and with bacterial culture in a diagnostic laboratory : a comparison / J Clin Pathol 59:661~662
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