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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,653 - 1,665 (13page)
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Purpose This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. Materials and Methods The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Results Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. Conclusion Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
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참고문헌 (28)
참고문헌 신청
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Mehlen P / 2006 / Metastasis : a question of life or death / Nat Rev Cancer 6:449~458
Kim JJ / 2015 / Inefficiencies and high-value improvements in U.S. cervical cancer screening practice: a cost-effectiveness analysis / Ann Intern Med 163:589~597
Kodama J / 2010 / Prognostic factors in stage IB-IIB cervical adenocarcinoma patients treated with radical hysterectomy and pelvic lymphadenectomy / J Surg Oncol 101:413~417
Qiao L / 2018 / Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells / Cell Death Dis 9:583
Mehlen P / 2006 / Metastasis : a question of life or death / Nat Rev Cancer 6:449~458
Kim JJ / 2015 / Inefficiencies and high-value improvements in U.S. cervical cancer screening practice: a cost-effectiveness analysis / Ann Intern Med 163:589~597
Kodama J / 2010 / Prognostic factors in stage IB-IIB cervical adenocarcinoma patients treated with radical hysterectomy and pelvic lymphadenectomy / J Surg Oncol 101:413~417
Qiao L / 2018 / Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells / Cell Death Dis 9:583
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