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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제7호
- 발행연도
- 2019.1
- 수록면
- 1,155 - 1,164 (10page)
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초록· 키워드
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Lichens contain diverse bioactive secondary metabolites with various chemical and biological properties, which have been widely studied. However, details of the inhibitory mechanisms of their secondary metabolites against influenza A virus (IAV) have not been documented. Here, we investigated the antiviral effect of lichen extracts, obtained from South Korea, against IAV in MDCK cells. Of the lichens tested, Nipponoparmelia laevior (LC24) exhibited the most potent inhibitory effect against IAV infection. LC24 extract significantly increased cell viability, and reduced apoptosis in IAV-infected cells. The LC24 extract also markedly reduced (~ 3.2 logfold) IAV mRNA expression after 48 h of infection. To understand the antiviral mechanism of LC24 against IAV, proteomic (UPLC-HDMSE) analysis was performed to compare proteome modulation in IAV-infected (V) vs. mock (M) and LC24+IAV (LCV) vs. V cells. Based on Ingenuity Pathway Analysis (IPA), LC24 inhibited IAV infection by modulating several antiviral-related genes and proteins (HSPA4, HSPA5, HSPA8, ANXA1, ANXA2, HIF-1α, AKT1, MX1, HNRNPH1, HNRNPDL, PDIA3, and VCP) via different signaling pathways, including HIF-1α signaling, unfolded protein response, and interferon signaling. These molecules were identified as the specific biomarkers for controlling IAV in vitro and further confirmation of their potential against IAV in vivo is required. Our findings provide a platform for further studies on the application of lichen extracts against IAV.
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참고문헌 (49)
참고문헌 신청
Long JS / 2019 / Host and viral determinants of influenza A virus species specificity / Nat. Rev. Microbiol 17:67~81
Dou D / 2018 / Influenza A virus cell entry, replication, virion assembly and movement / Front Immunol 9:1581
Medina RA / 2018 / 1918 Influenza Virus: 100 years on, are we prepared against the next influenza pandemic? / Nat, Rev. Microbiol 16:61~62
WHO / 2019 / Influenza (seasonal) / Influenza
Ju H / 2017 / Inhibitors of influenza virus polymerase acidic(PA)endonuclease : contemporary developments and perspectives / J. Med. Chem 60:3533~3551
Dou D / 2018 / Influenza A virus cell entry, replication, virion assembly and movement / Front Immunol 9:1581
Medina RA / 2018 / 1918 Influenza Virus: 100 years on, are we prepared against the next influenza pandemic? / Nat, Rev. Microbiol 16:61~62
WHO / 2019 / Influenza (seasonal) / Influenza
Ju H / 2017 / Inhibitors of influenza virus polymerase acidic(PA)endonuclease : contemporary developments and perspectives / J. Med. Chem 60:3533~3551
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