지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 10 (10page)
이용수
초록· 키워드
오류제보하기
Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height enhancement is limited to growth hormone treatment, which often results in side effects and clinical failure and is costly. Although recent studies have indicated the importance of paracrine signals in the growth plate for longitudinal bone growth, height-stimulating agents targeting the signaling pathways involved in growth plate maturation remain unavailable in the clinic. The Wnt/β-catenin pathway plays a major role in the maturation of growth plate chondrocytes. In this study, by using an ex vivo tibial culture system, we identified indirubin-3′-oxime (I3O) as a compound capable of enhancing longitudinal bone growth. I3O promoted chondrocyte proliferation and differentiation via activation of the Wnt/β-catenin pathway in vitro. Intraperitoneal injection of I3O in adolescent mice increased growth plate height along with incremental chondrocyte maturation. I3O promoted tibial growth without significant adverse effects on bone thickness and articular cartilage. Therefore, I3O could be a potential therapeutic agent for increasing height in children with growth retardation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
성장판 자극기기가 인체의 키 변화에 미치는 영향
전기전자재료학회논문지
2021 .09
-
Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail
BMB Reports
2015 .01
-
LGR5 Modulates Differentiated Phenotypes of Chondrocytes Through PI3K/AKT Signaling Pathway
조직공학과 재생의학
2024 .07
-
Optimized Cell Culture Media for 3D Culture of Human Articular Chondrocytes
한국생물공학회 학술대회
2016 .10
-
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Experimental and Molecular Medicine
2020 .02
-
Differentiation of adipose-derived stem cells into functional chondrocytes by a small molecule that induces Sox9
Experimental and Molecular Medicine
2020 .01
-
Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation
Experimental and Molecular Medicine
2015 .01
-
The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
Experimental and Molecular Medicine
2015 .01
-
Mechanosensitive β-catenin signaling regulates lymphatic vascular development
BMB Reports
2016 .01
-
Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer
BMB Reports
2016 .01
-
Cloning, Purification and NMR Studies on β-catenin C-terminal Domain
Journal of the Korean Magnetic Resonance Society
2017 .01
-
Curcumin polymeric micelles suppress the Wnt/Beta-Catenin signaling pathway target colon cancer
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
Curcumin polymeric micelles as inhibitor of the Wnt/beta-catenin signaling pathway target colon cancer
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis
Experimental and Molecular Medicine
2019 .01
-
Effects of Androgen Receptor Overexpression on Chondrogenic Ability of Rabbit Articular Chondrocytes
조직공학과 재생의학
2021 .01
-
The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology
Experimental and Molecular Medicine
2020 .08
-
Influence of Alginate/Demineralized Bone Particle Sponges Using Chondrocytes on the Articular Cartilage Tissue Engineering
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways
Experimental and Molecular Medicine
2024 .07
-
3D프린팅을 이용한 의료용 Bone Plate 구조해석 및 최적설계
대한기계학회 춘추학술대회
2024 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0