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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제5호
- 발행연도
- 2019.1
- 수록면
- 289 - 297 (9page)
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Background: SMAD family member 4 (SMAD4) has gained attention as a promising prognostic factor of colorectal cancer (CRC) as well as a key molecule to understand the tumorigenesis and progression of CRC. Methods: We retrospectively analyzed 1,281 CRC cases immunohistochemically for their expression status of SMAD4, and correlated this status with clinicopathologic and molecular features of CRCs. Results: A loss of nuclear SMAD4 was significantly associated with frequent lymphovascular and perineural invasion, tumor budding, fewer tumor-infiltrating lymphocytes, higher pT and pN category, and frequent distant metastasis. In contrast, tumors overexpressing SMAD4 showed a significant association with sporadic microsatellite instability. After adjustment for TNM stage, tumor differentiation, adjuvant chemotherapy, and lymphovascular invasion, the loss of SMAD4 was found to be an independent prognostic factor for worse 5-year progression-free survival (hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.01 to 1.60; p = .042) and 7-year cancerspecific survival (HR, 1.45; 95% CI, 1.06 to 1.99; p = .022). Conclusions: We confirmed the value of determining the loss of SMAD4 immunohistochemically as an independent prognostic factor for CRC in general. In addition, we identified some histologic and molecular features that might be clues to elucidate the role of SMAD4 in colorectal tumorigenesis and progression.
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참고문헌 (52)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Zhao M / 2018 / The role of TGF-beta/SMAD4 signaling in cancer / Int J Biol Sci 14:111~123
Schutte M. / 1999 / DPC4/SMAD4 gene alterations in human cancer, and their functional implications / Ann Oncol 1999; 10 Suppl 10(Suppl 4):56~59
Du Y / 2014 / Meta-analysis of the prognostic value of smad4 immunohistochemistry in various cancers / PLoS One 9:e110182
Wang JD / 2017 / Clinicopathological significance of SMAD4 loss in pancreatic ductal adenocarcinomas : a systematic review and meta-analysis / Oncotarget 8:16704~16711
Zhao M / 2018 / The role of TGF-beta/SMAD4 signaling in cancer / Int J Biol Sci 14:111~123
Schutte M. / 1999 / DPC4/SMAD4 gene alterations in human cancer, and their functional implications / Ann Oncol 1999; 10 Suppl 10(Suppl 4):56~59
Du Y / 2014 / Meta-analysis of the prognostic value of smad4 immunohistochemistry in various cancers / PLoS One 9:e110182
Wang JD / 2017 / Clinicopathological significance of SMAD4 loss in pancreatic ductal adenocarcinomas : a systematic review and meta-analysis / Oncotarget 8:16704~16711
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