지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제7호
- 발행연도
- 2019.1
- 수록면
- 1,144 - 1,154 (11page)
이용수
초록· 키워드
오류제보하기
There have been several studies regarding lichen-associated bacteria obtained from diverse environments. Our screening process identified 49 bacterial species in two lichens from the Himalayas: 17 species of Actinobacteria, 19 species of Firmicutes, and 13 species of Proteobacteria. We discovered five types of strong antimicrobial agent-producing bacteria. Although some strains exhibited weak antimicrobial activity, NP088, NP131, NP132, NP134, and NP160 exhibited strong antimicrobial activity against all multidrug-resistant strains. Polyketide synthase (PKS) fingerprinting revealed results for 69 of 148 strains; these had similar genes, such as fatty acid-related PKS, adenylation domain genes, PfaA, and PksD. Although the association between antimicrobial activity and the PKS fingerprinting results is poorly resolved, NP160 had six types of PKS fingerprinting genes, as well as strong antimicrobial activity. Therefore, we sequenced the draft genome of strain NP160, and predicted its secondary metabolism using antiSMASH version 4.2. NP160 had 46 clusters and was predicted to produce similar secondary metabolites with similarities of 5–100%. Although NP160 had 100% similarity with the alkylresorcinol biosynthetic gene cluster, our results showed low similarity with existing members of this biosynthetic gene cluster, and most have not yet been revealed. In conclusion, we expect that lichen-associated bacteria from the Himalayas can produce new secondary metabolites, and we found several secondary metabolite-related biosynthetic gene clusters to support this hypothesis.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
White PA / 2014 / Antioxidant activity and mechanisms of action of natural compounds, isolated from lichens : a systematic review / Molecules 19:14496~14527
He H / 2005 / Lichenicolins A and B, new bisnaphthopyrones from an unidentified lichenicolous fungus, strain LL-RB0668 / J. Antibiot. Tokyo 58:731~736
Oksanen I / 2004 / Discovery of rare and highly toxic microcystins from lichen-associated cyanobacterium Nostoc sp, strain IO-102-I / Appl. Environ. Microbiol 70:5756~5763
Mushegian AA / 2011 / Bacterial diversity across individual lichens / Appl. Environ. Microbiol 77:4249~4252
Parrot D / 2016 / Review-lichen-associated bacteria as a hot spot of chemodiversity : focus on uncialamycin, a promising compound for future medicinal applications / Planta Med 82:1143~1152
He H / 2005 / Lichenicolins A and B, new bisnaphthopyrones from an unidentified lichenicolous fungus, strain LL-RB0668 / J. Antibiot. Tokyo 58:731~736
Oksanen I / 2004 / Discovery of rare and highly toxic microcystins from lichen-associated cyanobacterium Nostoc sp, strain IO-102-I / Appl. Environ. Microbiol 70:5756~5763
Mushegian AA / 2011 / Bacterial diversity across individual lichens / Appl. Environ. Microbiol 77:4249~4252
Parrot D / 2016 / Review-lichen-associated bacteria as a hot spot of chemodiversity : focus on uncialamycin, a promising compound for future medicinal applications / Planta Med 82:1143~1152
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Convergence of Distinct Secondary Metabolite Biosynthetic Gene Clusters Driving Chemical Innovation in Fungi
한국미생물학회 학술대회논문집
2022 .10
-
Synthetic Biology Tools for Novel Secondary Metabolite Discovery in Streptomyces
Journal of Microbiology and Biotechnology
2019 .01
-
Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyes Species
한국미생물학회 학술대회논문집
2019 .04
-
A Genome-Wide Analysis of Antibiotic Producing Genes in Streptomyces globisporus SP6C4
The Plant Pathology Journal
2021 .08
-
Genomics and LC-MS Reveal Diverse Active Secondary Metabolites in Bacillus amyloliquefaciens WS-
Journal of Microbiology and Biotechnology
2020 .01
-
A CRISPR/Cas9 Cleavage System for Capturing Fungal Secondary Metabolite Gene Clusters
Journal of Microbiology and Biotechnology
2021 .01
-
CumSiOm+1 클러스터(m = 0 - 7)의 분자구조 그리고 전기적 특성에 관한 이론 연구
대한화학회지
2016 .08
-
Enhancing performance of gene expression value prediction with cluster-based regression
Genes & Genomics
2021 .09
-
RecET Recombineering System for Markerless Integration of Heterologous Biosynthetic Gene Clusters into Chromosomal DNA of Pseudomonas putida
한국미생물학회 학술대회논문집
2018 .04
-
Comparative Genomics Reveals the Core and Accessory Genomes of Streptomyces Species
Journal of Microbiology and Biotechnology
2015 .01
-
Elucidation of the Biosynthetic Pathway of Vitamin B Groups and Potential Secondary Metabolite Gene Clusters Via Genome Analysis of a Marine Bacterium Pseudoruegeria sp. M32A2M
Journal of Microbiology and Biotechnology
2020 .01
-
Complete genome sequence of Streptomyces sp. MMS22-DDSA8, a soil actinobacterium exhibiting antifungal activity
미생물학회지
2024 .06
-
Construction of Synaptic Neural Network for Genetic Interaction Analysis
Journal of The Korean Data Analysis Society
2021 .08
-
Expression of a Multi-Enzyme Resveratrol Biosynthetic Pathway with Designed Synthetic RBS in E. coli
한국미생물학회 학술대회논문집
2015 .04
-
An Efficient Markerless Deletion System Suitable for the Industrial Strains of Streptomyces
Journal of Microbiology and Biotechnology
2021 .12
-
The SnRK2 family in pepper (Capsicum annuum L.): genome-wide identifcation and expression analyses during fruit development and under abiotic stress
Genes & Genomics
2020 .01
-
Genome-wide identification, characterisation and expression profile analysis of DEAD-box family genes in sweet potato wild ancestor Ipomoea trifida under abiotic stresses
Genes & Genomics
2020 .01
-
LuxR-Type SCO6993 Negatively Regulates Antibiotic Production at the Transcriptional Stage by Binding to Promoters of Pathway-Specific Regulatory Genes in Streptomyces coelicolor
Journal of Microbiology and Biotechnology
2022 .09
-
군집화 기법을 활용한 산업집적분석 사례 연구
Journal of The Korean Data Analysis Society
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0