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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 223 - 233 (11page)
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Gadoxetic acid, a hepatocyte-specific magnetic resonance imaging (MRI) contrast agent, has emerged as an important tool for hepatocellular carcinoma (HCC) diagnosis. Gadoxetic acid-enhanced MRI is useful for the evaluation of earlystage HCC, diagnosis of HCC precursor lesions, and highly sensitive diagnosis of HCC. Furthermore, functional information provided by gadoxetic acid-enhanced MRI can aid in the characterization of focal liver lesions. For example, whereas lesions lack functioning hepatocytes appear hypointense in the hepatobiliary phase, preserved or enhanced expression of organic anion transporting polypeptides in some HCCs as well as focal nodular hyperplasia lead to hyperintensity in the hepatobiliary phase; and a targetoid appearance on transitional phase or hepatobiliary phase imaging can be helpful for identifying the histopathological composition of tumors. While gadoxetic acid-enhanced MRI may improve the sensitivity of HCC diagnosis and provide new insights into the characterization of focal liver lesions, there are many challenges associated with its use. This article reviews the pros and cons of HCC diagnosis with gadoxetic acidenhanced MRI and discuss some clues in the radiological differentiation of HCC from HCC mimickers. (
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참고문헌 (66)
참고문헌 신청
Global Burden of Disease Liver Cancer Collaboration / 2017 / The burden of primary liver cancer and underlying etiologies from 1990 to 2015at the global, regional, and national level : results from the global burden of disease study 2015 / JAMA Oncol 3:1683~1691
European Association for the Study of the Liver / 2018 / EASL clinical practice guidelines : management of hepatocellular carcinoma / J Hepatol 69:182~236
Marrero JA / 2018 / Diagnosis, staging, and management of hepatocellular carcinoma : 2018 practice guidance by the American Association for the Study of Liver Diseases / Hepatology 68:723~750
Joo I / 2016 / Recent advances in the imaging diagnosis of hepatocellular carcinoma : value of gadoxetic acid-enhanced MRI / Liver Cancer 5:67~87
Choi JY / 2014 / CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. extracellular agents, hepatobiliary agents, and ancillary imaging features / Radiology 273:30~50
European Association for the Study of the Liver / 2018 / EASL clinical practice guidelines : management of hepatocellular carcinoma / J Hepatol 69:182~236
Marrero JA / 2018 / Diagnosis, staging, and management of hepatocellular carcinoma : 2018 practice guidance by the American Association for the Study of Liver Diseases / Hepatology 68:723~750
Joo I / 2016 / Recent advances in the imaging diagnosis of hepatocellular carcinoma : value of gadoxetic acid-enhanced MRI / Liver Cancer 5:67~87
Choi JY / 2014 / CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. extracellular agents, hepatobiliary agents, and ancillary imaging features / Radiology 273:30~50
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