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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 270 - 283 (14page)
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초록· 키워드
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This study was aimed to explore if lncRNA MALAT1 would modify chemo-resistance of non-small cell lung cancer (NSCLC) cells by regulating miR-197-3p and p120 catenin (p120-ctn). Within this investigation, we totally recruited 326 lung cancer patients, and purchased 4 NSCLC cell lines of A549, H1299, SPC-A-1 and H460. Moreover, cisplatin, adriamycin, gefitinib and paclitaxel were arranged as chemotherapies, and half maximal inhibitory concentration (IC50) values were calculated to evaluate the chemo-resistance of the cells. Furthermore, mice models of NSCLC were also established to assess the impacts of MALAT1, miR-197-3p and p120-ctn on tumor growth. Our results indicated that MALAT1 and miR-197-3p were both over-expressed within NSCLC tissues and cells, when compared with normal tissues and cells (P < 0.05). The A549, H460, SPC-A-1 and SPC-A-1 displayed maximum resistances to cisplatin (IC50 = 15.70 μg/ml), adriamycin (IC50 = 5.58 μg/ml), gefitinib (96.82 μmol/L) and paclitaxel (141.97 nmol/L). Over-expression of MALAT1 and miR-197-3p, or under-expression of p120-ctn were associated with promoted viability and growth of the cancer cells (P < 0.05), and they could significantly strengthen the chemo-resistance of cancer cells (P < 0.05). MALAT1 Wt or p120-ctn Wt co-transfected with miR-197-3p mimic was observed with significantly reduced luciferase activity within NSCLC cells (P < 0.05). Finally, the NSCLC mice models were observed with larger tumor size and weight under circumstances of over-expressed MALAT1 and miR-197-3p, or under-expressed p120-ctn (P < 0.05). In conclusion, MALAT1 could alter chemo-resistance of NSCLC cells by targeting miR-197-3p and regulating p120-ctn expression, which might assist in improvement of chemo-therapies for NSCLC.
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등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Akbari Moqadam, F. / 2013 / MiR-125b, miR-100 and miR-99a coregulate vincristine resistance in childhood acute lymphoblastic leukemia / Leukemia Research 37:1315~1321
Camps, C. / 2009 / Importance of quality of life in patients with non-small-cell lung cancer / Clinical Lung Cancer 10:83~90
Cesana, M. / 2011 / A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA / Cell 147:358~369
Chartier, N. T. / 2007 / Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin(p120ctn)-dependent cell growth control : a new role for p120ctn in cancer / Cancer Research 67:9781~9790
Chen, W. / 2017 / MALAT1-miR-101-SOX9 feedback loop modulates the chemo-resistance of lung cancer cell to DDP via Wnt signaling pathway / Oncotarget 8:94317~94329
Camps, C. / 2009 / Importance of quality of life in patients with non-small-cell lung cancer / Clinical Lung Cancer 10:83~90
Cesana, M. / 2011 / A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA / Cell 147:358~369
Chartier, N. T. / 2007 / Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin(p120ctn)-dependent cell growth control : a new role for p120ctn in cancer / Cancer Research 67:9781~9790
Chen, W. / 2017 / MALAT1-miR-101-SOX9 feedback loop modulates the chemo-resistance of lung cancer cell to DDP via Wnt signaling pathway / Oncotarget 8:94317~94329
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