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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 353 - 359 (7page)
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Background and Purpose Cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) could be misleading in idiopathic normal-pressure hydrocephalus (iNPH). We therefore investigated the CSF biomarkers in 18F-florbetaben amyloid-negative positron-emission tomography (PET) [amyloid PET(-)] iNPH, amyloid-positive PET [amyloid PET(+)] AD, and cognitively normal (CN) subjects. Methods Ten amyloid PET(+) AD patients (56.7±5.6 years old, mean±standard deviation), 10 amyloid PET(-) iNPH patients (72.8±4.5 years old), and 8 CN subjects (61.2±6.5 years old) were included. We measured the levels of β-amyloid (Aβ)40, Aβ42, total tau (t-tau) protein, and phosphorylated tau (p-tau) protein in the CSF using enzyme-linked immunosorbent assays. Results The level of Aβ42 and the Aβ42/Aβ40 ratio in the CSF were significantly lower in AD than in iNPH or CN subjects. The Aβ40 level did not differ significantly between AD and iNPH (p=1.000), but it did between AD and CN subjects (p=0.032). The levels of both t-tau and p-tau were higher in AD than in iNPH or CN subjects. The levels of Aβ42, Aβ40, t-tau, and p-tau were lower in iNPH than in CN subjects, but there was no significant difference after controlling for age. Conclusions Our results suggest that the mechanism underlying low CSF Aβ levels differs between amyloid PET(-) iNPH and amyloid PET(+) AD subjects. The lower levels of all CSF biomarkers in iNPH patients might be due to reduced clearances from extracellular fluid and decreased brain metabolism of the periventricular zone in iNPH resulting from glymphatic dysfunction.
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참고문헌 (28)
참고문헌 신청
Adams RD / 1965 / Symptomatic occult hydrocephalus with “normal” cerebrospinal-fluid pressure. A treatable syndrome / N Engl J Med 273:117~126
Leinonen V / 2010 / Amyloid and tau proteins in cortical brain biopsy and Alzheimer’s disease / Ann Neurol 68:446~453
Golomb J / 2000 / Alzheimer’s disease comorbidity in normal pressure hydrocephalus : prevalence and shunt response / J Neurol Neurosurg Psychiatry 68:778~781
Blennow K / 2003 / CSF markers for incipient Alzheimer’s disease / Lancet Neurol 2:605~613
Lim TS / 2014 / Evaluation of coexistence of Alzheimer’s disease in idiopathic normal pressure hydrocephalus using ELISA analyses for CSF biomarkers / BMC Neurol 14:66
Leinonen V / 2010 / Amyloid and tau proteins in cortical brain biopsy and Alzheimer’s disease / Ann Neurol 68:446~453
Golomb J / 2000 / Alzheimer’s disease comorbidity in normal pressure hydrocephalus : prevalence and shunt response / J Neurol Neurosurg Psychiatry 68:778~781
Blennow K / 2003 / CSF markers for incipient Alzheimer’s disease / Lancet Neurol 2:605~613
Lim TS / 2014 / Evaluation of coexistence of Alzheimer’s disease in idiopathic normal pressure hydrocephalus using ELISA analyses for CSF biomarkers / BMC Neurol 14:66
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