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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 220 - 233 (14page)
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초록· 키워드
오류제보하기
Objective The purpose of the present study was to clarify the relationship between white matter tracts and cognitive symptoms in children with high-functioning autism spectrum disorder (ASD). Methods We examined the cognitive functions of 17 children with high-functioning ASD and 18 typically developing (TD) controls and performed diffusion tensor imaging (DTI) tractography. We compared the results between the groups and investigated the correlations between the cognitive scores and DTI parameters within each group. Results The Comprehension scores in the ASD group exhibited a positive correlation with mean diffusivity (MD) in the forceps minor (F minor). In the TD group, the Comprehension scores were positively correlated with fractional anisotropy (FA) in the right inferior fronto-occipital fasciculus (IFO) and left anterior thalamic radiation (ATR), and negatively correlated with MD in the left ATR, radial diffusivity (RD) in the right IFO, and RD in the left ATR. Additionally, a positive correlation was observed between the Matching Numbers scores and MD in the left uncinate fasciculus and F minor, and RD in the F minor. Furthermore, the Sentence Questions scores exhibited a positive correlation with RD in the right inferior longitudinal fasciculus. Relative to TD controls, the specific tract showing a strong correlation with the cognitive scores was reduced in the ASD group. Conclusion Our findings indicate that white matter tracts connecting specific brain areas may exhibit a weaker relationship with cognitive functions in children with ASD, resulting in less efficient cognitive pathways than those observed in TD children.
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등록된 정보가 없습니다.
참고문헌 (75)
참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and Statistical Manual of Mental Disorders, DSM-5 / American Psychiatric Association
Lai MC / 2014 / Autism / Lancet 383:896~910
Durrleman S / 2015 / Complex syntax in autism spectrum disorders : a study of relative clauses / Int J Lang Commun Disord 50:260~267
Ozonoff S / 1991 / Executive function deficits in high-functioning autistic individuals : relationship to theory of mind / J Child Psychol Psychiatry 32:1081~1105
Hill EL / 2004 / Executive dysfunction in autism / Trends Cogn Sci 8:26~32
Lai MC / 2014 / Autism / Lancet 383:896~910
Durrleman S / 2015 / Complex syntax in autism spectrum disorders : a study of relative clauses / Int J Lang Commun Disord 50:260~267
Ozonoff S / 1991 / Executive function deficits in high-functioning autistic individuals : relationship to theory of mind / J Child Psychol Psychiatry 32:1081~1105
Hill EL / 2004 / Executive dysfunction in autism / Trends Cogn Sci 8:26~32
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