지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 160 - 168 (9page)
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초록· 키워드
오류제보하기
Purpose: To search the salivary factors that objectively indicate an pain in myalgia patients with temporomandibular joint disorder (TMD) and determine the possibility of the factors as pain-biomarkers.
Methods: Participants consisted of pain-free 15 persons (male 7, female 8, mean age±standard deviation (SD); 26.8±16.04 years) and 45 myalgia patients with TMD (male 21, female 24, mean age±SD; 27.98±13.01 years). They were divided into a pain-free group (numerical rating scale [NRS] score 0), a mild pain group (NRS 1-4), a moderate pain group (NRS 5-6), and a severe pain group (NRS 7-10) and members of all groups were age, sex matched. Interleukin-8 (IL-8) and matrix metalloprotease 9 (MMP-9) were selected as pain biomarkers, by searching the Gene Expression Omnibus database and analyzing pain-related genes. Enzyme-linked immunosorbent assays were used to measure the concentration of IL-8 and MMP-9 in the patients’ saliva.
Results: IL-8 and MMP-9 levels were statistically significantly higher in pain groups than in the pain-free group. Greater differences were observed in patients with acute pain (with painful duration under 3 months) than in the control group and in female patients than in male.
Conclusions: Salivary IL-8 and MMP-9 may play a role as biomarkers of myalgia in patients with TMD.
Methods: Participants consisted of pain-free 15 persons (male 7, female 8, mean age±standard deviation (SD); 26.8±16.04 years) and 45 myalgia patients with TMD (male 21, female 24, mean age±SD; 27.98±13.01 years). They were divided into a pain-free group (numerical rating scale [NRS] score 0), a mild pain group (NRS 1-4), a moderate pain group (NRS 5-6), and a severe pain group (NRS 7-10) and members of all groups were age, sex matched. Interleukin-8 (IL-8) and matrix metalloprotease 9 (MMP-9) were selected as pain biomarkers, by searching the Gene Expression Omnibus database and analyzing pain-related genes. Enzyme-linked immunosorbent assays were used to measure the concentration of IL-8 and MMP-9 in the patients’ saliva.
Results: IL-8 and MMP-9 levels were statistically significantly higher in pain groups than in the pain-free group. Greater differences were observed in patients with acute pain (with painful duration under 3 months) than in the control group and in female patients than in male.
Conclusions: Salivary IL-8 and MMP-9 may play a role as biomarkers of myalgia in patients with TMD.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (50)
참고문헌 신청
Montes-Sandoval L / 1999 / An analysis of the concept of pain / J Adv Nurs 29:935~941
Shibata M / 2013 / Salivary biomarkers are not suitable for pain assessment in newborns / Early Hum Dev 89:503~506
Sobas EM / 2016 / Reliability of potential pain biomarkers in the saliva of healthy subjects: inter-individual differences and intersession variability / PLoS One 11:e0166976
Von Korff M / 2000 / Assessing global pain severity by self-report in clinical and health services research / Spine (Phila Pa 1976) 25:3140~3151
Williamson A / 2005 / Pain: a review of three commonly used pain rating scales / J Clin Nurs 1:798~804
Shibata M / 2013 / Salivary biomarkers are not suitable for pain assessment in newborns / Early Hum Dev 89:503~506
Sobas EM / 2016 / Reliability of potential pain biomarkers in the saliva of healthy subjects: inter-individual differences and intersession variability / PLoS One 11:e0166976
Von Korff M / 2000 / Assessing global pain severity by self-report in clinical and health services research / Spine (Phila Pa 1976) 25:3140~3151
Williamson A / 2005 / Pain: a review of three commonly used pain rating scales / J Clin Nurs 1:798~804
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