지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The unintentional reversion of various attenuated and inactivated vaccines has led the way of discovering and development of the virus like particles (VLPs) in the 1970s and 80s. The VLPs contain only the antigenic determinant portion of the structure of a target virus that is able to produce the same immune responses like the original viruses, however, since the particles do not contain any genetic material, the particles can’t infect like the actual viruses. They are able to induce both the humoral and cell mediated immune responses. Since infection doesn’t occur, this technology is a safe and reliable way to combat infectious diseases. Currently, VLPs are produced for a good number of infectious diseases and researches are going on to develop VLPs against many more diseases. Based on the structure, VLPs can be divided into two types: enveloped and non-enveloped VLPs. Enveloped VLPs have greater flexibility. To produce VLPs, various expression systems can be used: yeast, bacterial, mammalian, insect, and plant cells can be used. Insect cell culture system is mainly used in VLP production. The appropriate system should be determined based on the VLP type in question. The production and purification of all the VLPs are quite similar: the cloning of the gene for the antigenic portion, cell harvesting, disruption (if necessary), clarification, concentration and characterization, these steps are done using various means. This review summarizes the types of VLPs, their immunogenic properties, various expression systems that can be used for production and the production procedures of various VLPs.
목차
Types of VLPs on the Basis of Structure
Immunogenic Mechanisms
Expression Systems for VLP Production
Production and Purification of Some VLP Vaccines
Quantification and Characterization of VLPs
Summary and Future Prospects
Conclusion
References
참고문헌 (101)
참고문헌 신청
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Antonis AF / 2006 / A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure / Vaccine 24:5481~5490
Aucoin MG / 2007 / Virus-like particle and viral vector production using the baculovirus expression vector system/insect cell system / Methods Mol. Biol 388:281~296
Baker TS / 1991 / Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction / Biophys. J 60:1445~1456
Anderson LJ / 1990 / Human parvoviruses / J. Infect. Dis 161:603~608
Antonis AF / 2006 / A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure / Vaccine 24:5481~5490
Aucoin MG / 2007 / Virus-like particle and viral vector production using the baculovirus expression vector system/insect cell system / Methods Mol. Biol 388:281~296
Baker TS / 1991 / Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction / Biophys. J 60:1445~1456
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UCI(KEPA) : I410-ECN-0101-2020-475-000450036