Complications and local relapse after intraoperative low-voltage X-ray radiotherapy in breast cancer

Ana Alicia Tejera Hernández; Víctor Manuel Vega Benítez; Juan Carlos Rocca Cardenas; Neith Ortega Pérez; Nieves Rodriguez Ibarria; Juan Carlos Díaz Chico; Juan José García-Granados Alayón; Pedro Pérez Correa; Juan Ramón Hernández Hernández

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저자정보: Ana Alicia Tejera Hernández (University of Las Palmas de Gran Canaria) Víctor Manuel Vega Benítez (University of Las Palmas de Gran Canaria) Juan Carlos Rocca Cardenas (University of Las Palmas de Gran Canaria) Neith Ortega Pérez (University of Las Palmas de Gran Canaria) Nieves Rodriguez Ibarria (University of Las Palmas de Gran Canaria) Juan Carlos Díaz Chico (University of Las Palmas de Gran Canaria) Juan José García-Granados Alayón (University of Las Palmas de Gran Canaria) Pedro Pérez Correa (University of Las Palmas de Gran Canaria) Juan Ramón Hernández Hernández (University of Las Palmas de Gran Canaria)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.98 No.6

발행연도: 2020.6

수록면: 299 - 306 (8page)

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Purpose: To study those factors that influence the occurrence of surgical complications and local relapse in patients intervened for breast cancer and receiving intraoperative radiotherapy.
Methods: Observational study on patients intervened for breast cancer with conservative surgery and intraoperative radiotherapy with low-voltage X-ray energy source (INTRABEAM), from 2015 to 2017 with 24 months minimum followup. Variables possibly associated to the occurrence of postoperative complications were analyzed with the Student t-test and the Fisher exact test; P < 0.05 considered significant. Subsequently, the construction of multiple multivariate analysis models began, thus building a logistic regression analysis using the IBM SPSS Statistics ver. 23 software. Local relapse was described.
Results: The study included 102 patients, mean age of 61.2 years; mean global size of tumor, 12.2 mm. Complications occurred in 29.4%. Fibrosis was the most frequently observed complication, followed by postoperative seroma. Using a 45 mm or larger applicator were significantly associated with the occurrence of complications. Tumor size 2 cm or larger and reintervention showed borderline significant association. Only one case of local relapse was observed.
Conclusion: Certain factors may increase the risk of complication after the use of intraoperative radiotherapy. Using external complementary radiotherapy does not seem to increase the rate of complications. Select patients and the involvement of a multidisciplinary team are essential for achieving good results.

#Breast neoplasms #Complications #Local neoplasm recurrence #Radiotherapy

참고문헌 (30)

참고문헌 신청

Orecchia R / 2003 / Intraoperative radiation therapy with electrons(ELIOT)in early-stage breast cancer / Breast 12:483~490

Vaidya JS / 2010 / Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer(TARGIT-A trial) : an international, prospective, randomised, non-inferiority phase 3 trial / Lancet 376:91~102

Vaidya JS / 2014 / Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer : 5-year results for local control and overall survival from the TARGIT-A randomised trial / Lancet 383:603~613

Smith BD / 2009 / Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology(ASTRO) / J Am Coll Surg 209:269~277

Morlino A / 2017 / IORT in breast cancer. Our experience of the first patients treated / Ann Ital Chir 88:253~257

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