지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
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To retain valuable resources, organisms adopt several strategies including coprophagy. Cells covering the outer skin and internal digestive lumen are actively recycled to maintain their integrity. In present study, we suggested that the small intestine can consume dead cells in a manner similar to how it consumes protein from the diet. We examined the eluates from five segments of the mouse small intestine and cecum and 2 segments of the large intestine and small intestine tissue, and detected immunoreactivity with eukaryotic caveolin-1 and β-actin antibodies only in the cecum and 2 segments from the large intestine. Bacterial agitation of the mouse intestine with Shigella disrupted the architecture and absorptive function of the small intestine. Small intestine eluates were immunoreactive with murine caveolin-1 and contained heme as determined by dot blot analysis. We concluded that the body conserves resources in the small intestine by disposing of and recycling shedded cells.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
References
참고문헌 (17)
참고문헌 신청
Bullen TF, Forrest S, Campbell F, Dodson AR, Hershman MJ, Pritchard DM, Turner JR Montrose MH, Watson AJ. Characterization of epithelial cell shedding from human small intestine. Lab. Invest. 86: 1052-1063 (2006)
Chang SY, Lee SN, Yang JY, Kim DW, Yoon JH, Ko HJ, Ogawa M, Sasakawa C, Kweon MN Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: A murine model. PLoS One 8: e81095 (2013)
Cummings JH, Macfarlane GT. Role of intestinal bacteria in nutrient metabolism. JPEN J. Parenter. Enteral Nutr. 21: 357-365 (1997)
Hausmann M. How bacteria-induced apoptosis of intestinal epithelial cells contributes to mucosal inflammation. Int. J. Inflam. 2010: 574568 (2010)
Iwanaga T, Han H, Adachi K, Fujita T. A novel mechanism for disposing of effete epithelial cells in the small intestine of guinea pigs. Gastroenterology 5: 1089-1097 (1993)
Chang SY, Lee SN, Yang JY, Kim DW, Yoon JH, Ko HJ, Ogawa M, Sasakawa C, Kweon MN Autophagy controls an intrinsic host defense to bacteria by promoting epithelial cell survival: A murine model. PLoS One 8: e81095 (2013)
Cummings JH, Macfarlane GT. Role of intestinal bacteria in nutrient metabolism. JPEN J. Parenter. Enteral Nutr. 21: 357-365 (1997)
Hausmann M. How bacteria-induced apoptosis of intestinal epithelial cells contributes to mucosal inflammation. Int. J. Inflam. 2010: 574568 (2010)
Iwanaga T, Han H, Adachi K, Fujita T. A novel mechanism for disposing of effete epithelial cells in the small intestine of guinea pigs. Gastroenterology 5: 1089-1097 (1993)
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UCI(KEPA) : I410-ECN-0101-2020-594-000670809