Prevalence of Carbapenem-Resistant Enterobacteriaceae in Seoul, Korea

Sang-Hun Park; Jin-Seok Kim; Hee-Soon Kim; Jin-Kyung Yu; Sung-Hee Han; Min-Ji Kang; Chae-Kyu Hong; Sang-Me Lee; Young-Hee Oh

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저자정보: Sang-Hun Park (Seoul Metropolitan Government Research Institute of Public Health and Environment) Jin-Seok Kim (Seoul Metropolitan Government Research Institute of Public Health and Environment) Hee-Soon Kim (Seoul Metropolitan Government Research Institute of Public Health and Environment) Jin-Kyung Yu (Seoul Metropolitan Government Research Institute of Public Health and Environment) Sung-Hee Han (Seoul Metropolitan Government Research Institute of Public Health and Environment) Min-Ji Kang (Seoul Metropolitan Government Research Institute of Public Health and Environment) Chae-Kyu Hong (Seoul Metropolitan Government Research Institute of Public Health and Environment) Sang-Me Lee (Seoul Metropolitan Government Research Institute of Public Health and Environment) Young-Hee Oh (Seoul Metropolitan Government Research Institute of Public Health and Environment)

저널정보: 대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.50 No.2

발행연도: 2020.6

수록면: 107 - 116 (10page)

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The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is increasing globally. However, a few studies have addressed their epidemiology in Seoul, Korea. In this study, we conducted one-year surveillance of CRE among 1,468 clinical isolates of Enterobacteriaceae at the hospital in Seoul with molecular characterization of carbapenemase genes. About 85% of CRE-positive samples were isolated from the elderly age group (above 60 years). The most common isolated organisms were Klebsiella pneumoniae (K. pneumoniae) (56.5%) and Escherichia coli (E.coli) (17.0%). We detected six different Carbapenemase-producing Enterobacteriaceae (CPE) of blaKPC, blaNDM, blaOXA, blaVIM, blaIMP, and blaGES alone or in combination with other bla genes. Typically, 853 (58.1%) isolates were tested positive for at least one CPE. KPC (K. pneumoniae carbapenemase)-2 was the most common CPE type (46.0%) followed by NDM (New Delhi metallo-β-lactamase)-1 (5.9%). KPC-2 was most commonly found in K. pneumoniae (494/676 isolates [73.1%]) and E.coli (107/676 isolates [15.8%]), whereas NDM-1 was commonly found in Enterobacter cloacae complex (20/86 isolates [23.3%]). Detailed information and molecular characteristics of CPE is essential to prevent the spread of these pathogens.

#Carbapenem-resistant Enterobacteriaceae (CRE) #Carbapenemase-producing Enterobacteriaceae (CPE) #Klebsiella pneumoniae

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