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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제23권 제4호
- 발행연도
- 2020.1
- 수록면
- 397 - 404 (8page)
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초록· 키워드
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Purpose: Synbiotics can alleviate some intestinal pathologies or prevent trigger mechanisms for some diseases such as celiac disease (CD). If patients with high levels of anti-tissue transglutaminase (anti-tTG) immunoglobulin A (IgA) antibodies have normal duodenal histology, they are followed as potential CD patients. The aim of this study was to investigate the effect of synbiotic use on the blood levels of anti-tTG antibodies in children. Methods: Eighty-two patients with high anti-tTG levels were included in this study. Patients were randomly divided into two groups. The synbiotic group was treated with a daily dose of a synbiotic including multi-strain probiotics for 20 days. The control group was not administered any medication. Anti-tTG values at baseline and repeat measurements and the percentage change in anti-tTG levels between groups were compared. Results: The anti-tTG level at baseline was 36 U/mL (interquartile range [IQR], 26.4–68 U/mL) in the synbiotic group, and it decreased significantly to 13 U/mL (IQR, 6.5–27.5 U/mL) after 20 days (p<0.05). The anti-tTG level at baseline was 46 U/mL (IQR, 31–89 U/mL) in the control group, which also decreased significantly to 23 U/mL (IQR, 7–41 U/mL) after 20 days (p<0.05). Anti-tTG levels exhibited 73% and 56% decreases in the synbiotic and control groups, respectively (p<0.05). Conclusion: It may be speculated that a synbiotic supplementation can contribute to decreasing anti-tTG levels in children with potential CD.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Iannitti T / 2010 / Therapeutical use of probiotic formulations in clinical practice / Clin Nutr 29:701~725
Gagliardi A / 2018 / Rebuilding the gut microbiota ecosystem / Int J Environ Res Public Health 15:1679
Husby S / 2012 / European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease / J Pediatr Gastroenterol Nutr 54:136~160
Guandalini S / 2014 / Celiac disease : a review / JAMA Pediatr 168:272~278
Silvester JA / 2017 / Tests for serum transglutaminase and endomysial antibodies do not detect most patients with celiac disease and persistent villous atrophy on gluten-free diets : a meta-analysis / Gastroenterology 153:689~701
Gagliardi A / 2018 / Rebuilding the gut microbiota ecosystem / Int J Environ Res Public Health 15:1679
Husby S / 2012 / European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease / J Pediatr Gastroenterol Nutr 54:136~160
Guandalini S / 2014 / Celiac disease : a review / JAMA Pediatr 168:272~278
Silvester JA / 2017 / Tests for serum transglutaminase and endomysial antibodies do not detect most patients with celiac disease and persistent villous atrophy on gluten-free diets : a meta-analysis / Gastroenterology 153:689~701
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