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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: Online magnetic resonance-guided adaptive radiotherapy (MRgART), an emerging technique, is used to address the change in anatomical structures, such as treatment target region, during the treatment period. However, the electron density map used for dose calculation differs from that for daily treatment, owing to the variation in organ location and, notably, air pockets. In this study, we evaluate the dosimetric effect of electron density override on air pockets during online ART for pancreatic cancer cases. Methods: Five pancreatic cancer patients, who were treated with MRgART at the Seoul National University Hospital, were enrolled in the study. Intensity modulated radiation therapy plans were generated for each patient with 60Co beams on a ViewrayTM system, with a 45 Gy prescription dose for stereotactic body radiation therapy. During the treatment, the electron density map was modified based on the daily MR image. We recalculated the dose distribution on the plan, and the dosimetric parameters were obtained from the dose volume histograms of the planning target volume (PTV) and organs at risk. Results: The average dose difference in the PTV was 0.86Gy, and the observed difference at the maximum dose was up to 2.07 Gy. The variation in air pockets during treatment resulted in an under- or overdose in the PTV. Conclusions: We recommend the re-contouring of the air pockets to deliver an accurate radiation dose to the target in MRgART, even though it is a time-consuming method.
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참고문헌 (14)
참고문헌 신청
Hidalgo M / 2010 / Pancreatic cancer / N Engl J Med 362:1605~1617
Wang F / 2011 / The role of radiotherapy in management of pancreatic cancer / J Gastrointest Oncol 2:157~167
Boldrini L / 2019 / Online adaptive magnetic resonance guided radiotherapy for pancreatic cancer : state of the art, pearls and pitfalls / Radiat Oncol 14:71
Rudra S / 2019 / Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer / Cancer Med 8:2123~2132
Berger T / 2017 / Impact of bowel gas and body outline variations on total accumulated dose with intensity-modulated proton therapy in locally advanced cervical cancer patients / Acta Oncol 56:1472~1478
Wang F / 2011 / The role of radiotherapy in management of pancreatic cancer / J Gastrointest Oncol 2:157~167
Boldrini L / 2019 / Online adaptive magnetic resonance guided radiotherapy for pancreatic cancer : state of the art, pearls and pitfalls / Radiat Oncol 14:71
Rudra S / 2019 / Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer / Cancer Med 8:2123~2132
Berger T / 2017 / Impact of bowel gas and body outline variations on total accumulated dose with intensity-modulated proton therapy in locally advanced cervical cancer patients / Acta Oncol 56:1472~1478
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