지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 619 - 624 (6page)
이용수
초록· 키워드
오류제보하기
The primary cilium is a microtubule-based structure projecting from a cell. Although the primary cilium shows no motility, it can recognize environmental stimuli. Thus, ciliary defects cause severe abnormalities called ciliopathies. Ciliogenesis is a very complex process and involves a myriad of components and regulators. In order to excavate the novel positive regulators of ciliogenesis, we performed mRNA microarray using starved NIH/3T3 cells. We selected 62 murine genes with corresponding human orthologs, with significantly upregulated expression at 24 h after serum withdrawal. Finally, calpain-6 was selected as a positive regulator of ciliogenesis. We found that calpain-6 deficiency reduced the percentage of ciliated cells and impaired sonic hedgehog signaling. It has been speculated that this defect might be associated with decreased levels of -tubulin acetylation at lysine 40. This is the first study to report a novel role of calpain-6 in the formation of primary cilia.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Gerdes JM / 2009 / The vertebrate primary cilium in development, homeostasis, and disease / Cell 137:32~45
Pala R / 2017 / Primary Cilium-Dependent Signaling Mechanisms / Int J Mol Sci 18:2272
Sung CH / 2013 / The roles of evolutionarily conserved functional modules in ciliarelated trafficking / Nat Cell Biol 15:1387~1397
Pihan GA / 2013 / Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer / Front Oncol 3:277
Tanos BE / 2013 / Centriole distal appendages promote membrane docking, leading to cilia initiation / Genes Dev 27:163~168
Pala R / 2017 / Primary Cilium-Dependent Signaling Mechanisms / Int J Mol Sci 18:2272
Sung CH / 2013 / The roles of evolutionarily conserved functional modules in ciliarelated trafficking / Nat Cell Biol 15:1387~1397
Pihan GA / 2013 / Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer / Front Oncol 3:277
Tanos BE / 2013 / Centriole distal appendages promote membrane docking, leading to cilia initiation / Genes Dev 27:163~168
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Primary cilia in energy balance signaling and metabolic disorder
BMB Reports
2015 .01
-
자기구동 자가조립 섬모를 이용한 다양한 인공 섬모 운동
제어로봇시스템학회 국내학술대회 논문집
2021 .06
-
Hypothalamic primary cilium: A hub for metabolic homeostasis
Experimental and Molecular Medicine
2021 .07
-
Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development
BMB Reports
2020 .01
-
Ciliary subcompartments: how are they established and what are their functions?
BMB Reports
2015 .01
-
일차 섬모 발현에 따른 암 세포의 기계적 특성 변화
대한기계학회 춘추학술대회
2022 .04
-
폐 상피세포의 섬모발생에 대한 미세 중력의 영향 분석
대한기계학회 춘추학술대회
2024 .11
-
Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production
Experimental and Molecular Medicine
2020 .01
-
Polyinosinic:polycytidylic acid regulates the regenerative migration of BEAS-2B bronchial epithelial cells via primary cilium formation
대한기계학회 춘추학술대회
2022 .04
-
재구성 및 적응형 구동을 위한 온도 반응형 자기 섬모
제어로봇시스템학회 국내학술대회 논문집
2023 .06
-
Electro-actuated metal/polymer hybrid nanorod array mimicking motile cilia
대한기계학회 춘추학술대회
2017 .05
-
Entropy analysis in a cilia transport of nanofluid under the influence of magnetic field
Nuclear Engineering and Technology
2017 .01
-
Temperature sensor의 온도 측정 오차를 줄이기 위한 Current Regulator 구현
대한전자공학회 학술대회
2024 .06
-
Improved Production of Lactic acid in Saccharomyces Cerevisiae through Knockout of a Regulator Gene
한국생물공학회 학술대회
2015 .04
-
Expression profiling identified IL-8 as a regulator of homotypic cell-in-cell formation
BMB Reports
2018 .01
-
CMOS 트랜지스터로 구성된 온도 보상된 LDO Regulator 설계
대한전자공학회 학술대회
2015 .06
-
Improvement in operating performance of an electric regulator applied on CNG fueled vehicles
한국자동차공학회 춘계학술대회
2018 .06
-
LPG Regulator의 환경 조건에 대한 Seal 기밀성능 예측
한국자동차공학회 춘계학술대회
2020 .07
-
Development of Novel Suspending Cell Culture Substrates for ex vivo Cell-gene Therapy
한국생물공학회 학술대회
2018 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0