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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 121 - 125 (5page)
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The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell markers have been successfully identified, there is no universal stem cell marker, which is exclusively expressed in all stem cells. Here, we discuss the roles of master developmental regulator RUNX1 in stem cells and the development of a 270 base pair fragment of the Runx1 enhancer (eR1) for use as stem cell marker. Using eR1 to identify stem cells offers a distinct advantage over gene promoters, which might not be expressed exclusively in stem cells. Moreover, RUNX1 has been strongly implicated in various cancer types, such as leukemia, breast, esophageal, prostate, oral, skin, and ovarian cancers?it has been suggested that RUNX1 dysfunction promotes stem cell dysfunction and proliferation. As tissue stem cells are potential candidates for cancer cells-of-origin and cancer stem cells, we will also discuss the use of eR1 to target oncogenic gene manipulations in stem cells and to track subsequent neoplastic changes.
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참고문헌 (32)
참고문헌 신청
Adam, R. C. / 2015 / Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice / Nature 521:366~370
Bee, T. / 2010 / Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis / Blood 115:3042~3050
Blyth, K. / 2005 / The RUNX genes : gain or loss of function in cancer / Nat. Rev. Cancer 5:376~387
Burns, C. E. / 2005 / Hematopoietic stem cell fate is established by the Notch-Runx pathway / Genes Dev 19:2331~2342
Choi, E. / 2016 / Expression of activated Ras in gastric chief cells of mice leads to the full spectrum of metaplastic lineage transitions / Gastroenterology 150:918~930
Bee, T. / 2010 / Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis / Blood 115:3042~3050
Blyth, K. / 2005 / The RUNX genes : gain or loss of function in cancer / Nat. Rev. Cancer 5:376~387
Burns, C. E. / 2005 / Hematopoietic stem cell fate is established by the Notch-Runx pathway / Genes Dev 19:2331~2342
Choi, E. / 2016 / Expression of activated Ras in gastric chief cells of mice leads to the full spectrum of metaplastic lineage transitions / Gastroenterology 150:918~930
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