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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 182 - 190 (9page)
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초록· 키워드
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Periodontitis is an inflammatory disease of the supportive tissues surrounding the teeth, and is characterized by irreversible destruction of the gingiva, periodontal ligament (PDL), and alveolar bone, which results in the loss of teeth. In the present study, we elucidated the correlation between periodontitis and apelin (APLN), an adipokine and a regulatory peptide, respectively, which are involved in inflammation and bone remodeling. The expression of APLN is negatively correlated with periodontitis progression in gingival tissue. In addition, treatment with TNF-α downregulated the expression of APLN in PDL cells and gingival fibroblasts, indicating the protective role played by APLN against periodontitis progression. The overexpression of APLN or treatment with exogenous APLN suppressed the TNF-α- mediated catabolic gene expression of MMP1 , IL6 , and PTGS2 in PDL cells. Moreover, the inhibition of the APLN- APJ axis by ML221, an APJ inhibitor, induced catabolic gene expression in PDL cells. Thus, the results of this study provided evidence to support APLN as a regulatory factor of the inflammatory response during periodontitis.
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참고문헌 (38)
참고문헌 신청
Thomas F. Flemmig / 1999 / Periodontitis / Annals of Periodontology 4(1):32~37
Bruce L Pihlstrom / 2005 / Periodontal diseases / The Lancet 366(9499):1809~1820
George Hajishengallis / 2015 / Periodontitis: from microbial immune subversion to systemic inflammation / Nature Reviews Immunology 15(1):30~44
N. Scheres / 2011 / Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in interaction with Porphyromonas gingivalis / Journal of Periodontal Research 46(4):407~416
Cavalla Franco / 2017 / Matrix Metalloproteinases as Regulators of Periodontal Inflammation / International Journal of Molecular Sciences 18(2):440
Bruce L Pihlstrom / 2005 / Periodontal diseases / The Lancet 366(9499):1809~1820
George Hajishengallis / 2015 / Periodontitis: from microbial immune subversion to systemic inflammation / Nature Reviews Immunology 15(1):30~44
N. Scheres / 2011 / Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in interaction with Porphyromonas gingivalis / Journal of Periodontal Research 46(4):407~416
Cavalla Franco / 2017 / Matrix Metalloproteinases as Regulators of Periodontal Inflammation / International Journal of Molecular Sciences 18(2):440
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