지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 78 - 83 (6page)
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초록· 키워드
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Objectives: The discontinuation of bisphosphonate (BP) treatment before tooth extraction may induce medication-related osteonecrosis of the jaw (MRONJ). Whether the long-term discontinuation of BP treatment before tooth extraction affects the risk of developing MRONJ after tooth extraction or whether extended drug holidays induce systemic side effects remains unclear. The present study assessed the incidence of MRONJ among patients who underwent tooth extraction and did not discontinue BP therapy prior to the procedure. Materials and Methods: Patients were classified according to whether or not they discontinued BP therapy before tooth extraction. Differences in the incidence of MRONJ after tooth extraction were compared between the two groups using the chi-squared test.Results: The BP-continuation (BPC) and BP-discontinuation (BPDC) groups included 179 and 286 patients, respectively. One patient in the BPC group and no patients in the BPDC group developed MRONJ (P=0.385). The patients in the BPDC group stopped receiving BP therapy at a mean of 39.0±35.5 months prior to tooth extraction.Conclusion: The possibility of pre-existing MRONJ in the extraction area must be considered during the extraction procedure. Routine discontinu-ation of BP medications for several months before the extraction procedure should be carefully considered, as evidence of its efficacy in reducing the development of post-extraction MRONJ is limited.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Otto S / 2018 / Medication-related osteonecrosis of the jaw : prevention, diagnosis and management in patients with cancer and bone metastases / Cancer Treat Rev 69:177~187
Filleul O / 2010 / Bisphosphonate-induced osteonecrosis of the jaw : a review of 2, 400 patient cases / J Cancer Res Clin Oncol 136:1117~1124
Mozzati M / 2011 / Tooth extraction and oral bisphosphonates : comparison of different surgical protocols / Joint Bone Spine 78:647~648
Ji-Wan Kim / 2016 / Dental implant treatment after healing of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the same region: a case report / 대한구강악안면외과학회지 42(3):157~161
Yoneda T / 2010 / Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons / J Bone Miner Metab 28:365~383
Filleul O / 2010 / Bisphosphonate-induced osteonecrosis of the jaw : a review of 2, 400 patient cases / J Cancer Res Clin Oncol 136:1117~1124
Mozzati M / 2011 / Tooth extraction and oral bisphosphonates : comparison of different surgical protocols / Joint Bone Spine 78:647~648
Ji-Wan Kim / 2016 / Dental implant treatment after healing of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the same region: a case report / 대한구강악안면외과학회지 42(3):157~161
Yoneda T / 2010 / Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons / J Bone Miner Metab 28:365~383
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