지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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A complex and intricate cascades of gene expression is necessary for tooth development, and tooth eruption is one of main events during tooth development. Tooth eruption is considered to be strictly controlled either by signaling or extracellular molecules that are secreted by the tooth germs themselves. There have been numerous reports on the eruption-related molecules; however, there is still a lack of information regarding the preparation of the eruption pathway and the key tissue factors involved. This study aimed to localize the eruption-related molecules such as cyclophilin A (Cyp-A), extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase proteins (MMP-9), receptor activator of nuclear factor kappa-B ligand (RANKL), and osteoprotegerin (OPG) in the developing rat incisors. Immunofluorescence findings revealed that Cyp-A, EMMPRIN, OPG, and RANKL were expressed strongly in the dental lamina epithelium of the rat incisor germs during eruptive movement. OPG was also expressed in the osteoclasts in the apical region. MMP-9, a final tissue resolution molecule, was more widely localized in the area surrounding the erupting incisor. This study suggested that the dental lamina epithelium may play a key role in preparing eruption pathways for the incisor in rats.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Tetsuro Sameshima / 2000 / Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts / Cancer Letters 157(2):177~184
Johanna Pispa / 2003 / Mechanisms of ectodermal organogenesis / Developmental Biology 262(2):195~205
Vyacheslav Yurchenko / 2001 / CD147 Is a Signaling Receptor for Cyclophilin B / Biochemical and Biophysical Research Communications 288(4):786~788
P Nigro / 2013 / Cyclophilin A: a key player for human disease / Cell Death & Disease 4(10):e888~e888
Takahiro Oshiro / 2002 / Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice / The Anatomical Record 266(4):218~225
Johanna Pispa / 2003 / Mechanisms of ectodermal organogenesis / Developmental Biology 262(2):195~205
Vyacheslav Yurchenko / 2001 / CD147 Is a Signaling Receptor for Cyclophilin B / Biochemical and Biophysical Research Communications 288(4):786~788
P Nigro / 2013 / Cyclophilin A: a key player for human disease / Cell Death & Disease 4(10):e888~e888
Takahiro Oshiro / 2002 / Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice / The Anatomical Record 266(4):218~225
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