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The area of endoscopic application has been continuously expanded since its introduction in the last century and the frequency ofits use also increased stiffly in the last decades. Because gastrointestinal endoscopy is naturally exposed to diseased internal organsand contact with pathogenic materials, endoscopy mediated infection or disease transmission becomes a major concern in this field. Gastrointestinal endoscopy is not for single use and the proper reprocessing process is a critical factor for safe and reliable endoscopyprocedures. What needed in these circumstances is a practical guideline for reprocessing the endoscope and its accessories whichis feasible in the real clinical field to guarantee acceptable prevention of pathogen transmission. This guideline contains principlesand instructions of the reprocessing procedure according to the step by step. And it newly includes general information and updatedknowledge about endoscopy-mediated infection and disinfection. Multiple societies and working groups participated to revise;Korean Association for the Study of the Liver, the Korean Society of Infectious Diseases, Korean College of Helicobacter and UpperGastrointestinal Research, the Korean Society of Gastroenterology, Korean Society of Gastrointestinal Cancer, Korean Associationfor the Study of Intestinal Diseases, Korean Pancreatobiliary Association, the Korean Society of Gastrointestinal Endoscopy Nursesand Associates and Korean Society of Gastrointestinal Endoscopy. Through this cooperation, we enhanced communication andestablished a better concordance. We still need more researches in this field and fill up the unproven area. And our guidelines will berenewed accordingly.

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