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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 779 - 788 (10page)
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Purpose The purpose of this study was to identify the clinical utility of circulating tumor DNA (ctDNA) from ascites and serial plasma samples from epithelial ovarian cancer (EOC) patients. Materials and Methods Using targeted next-generation sequencing, we analyzed a total of 55 EOC samples including ctDNA from ascites and serial plasma and gDNA from tumor tissues. Tumor tissues and ascites were collected during debulking surgeries and plasma samples were collected before and after the surgeries. Because one EOC patient underwent secondary debulking surgery, a total of 11 tumor tissues, 33 plasma samples, and 11 ascites samples were obtained from the 10 patients. Results Of the 10 patients, nine (90%) contained somatic mutations in both tumor tissues and ascites ctDNA. This mutational concordance was confirmed through correlation analysis. The mutational concordance between ascites and tumor tissues was valid in recurrent/progressive ovarian cancer. TP53was the most frequently detected gene with mutations. ctDNA from serial plasma samples identified EOC progression/recurrence at a similar time or even more rapidly than cancer antigen 125, an established serum protein tumor marker for EOC. Conclusion Our data suggest that ascites ctDNA can be used to identify the mutational landscape of ovarian cancer for therapeutic strategy planning.
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참고문헌 (29)
참고문헌 신청
Torre LA / 2018 / Ovarian cancer statistics, 2018 / CA Cancer J Clin 68:284~296
Clarke-Pearson DL / 2009 / Clinical practice. Screening for ovarian cancer / N Engl J Med 361:170~177
Jayson GC / 2014 / Ovarian cancer / Lancet 384:1376~1388
Smolle E / 2014 / Malignant ascites in ovarian cancer and the role of targeted therapeutics / Anticancer Res 34:1553~1561
Ahmed N / 2013 / Getting to know ovarian cancer ascites : opportunities for targeted therapy-based translational research / Front Oncol 3:256
Clarke-Pearson DL / 2009 / Clinical practice. Screening for ovarian cancer / N Engl J Med 361:170~177
Jayson GC / 2014 / Ovarian cancer / Lancet 384:1376~1388
Smolle E / 2014 / Malignant ascites in ovarian cancer and the role of targeted therapeutics / Anticancer Res 34:1553~1561
Ahmed N / 2013 / Getting to know ovarian cancer ascites : opportunities for targeted therapy-based translational research / Front Oncol 3:256
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