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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 164 - 168 (5page)
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초록· 키워드
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Active surveillance culture (ASC) can help detect hidden reservoirs, but the routine use of ASC for extended spectrum β-lactamase-producing Enterobacteriaceae is controversial in an endemic situation. We aimed to determine the prevalence and risk factors of extended spectrum β-lactamase-producing Klebsiella pneumoniae (EBSL-Kpn) colonization among intensive care unit (ICU)-admitted patients. Prospective screening of ESBL-Kpn colonization was performed for ICU-admitted patients within 48 hours for two months. A perirectal swab sample was inoculated on MacConkey agar supplemented with 2 μg/mL ceftazidime. ESBL genotype was determined by PCR-sequencing, and clonal relatedness was evaluated by pulsed-field gel electrophoresis (PFGE). The risk factors of ESBL-Kpn colonization were evaluated. The ESBL-Kpn colonization rate among the 281 patients at ICU admission was 6.4% (18/281), and blaCTX-M-15 was detected in all isolates. ESBL producers also showed resistance to fluoroquinolone (38.9%, 7/18). All isolates had the same ESBL genotype (blaCTX-M-15) and a highly clustered PFGE pattern, suggesting cross-transmission without a documented outbreak. In univariate analysis, the risk factor for ESBL-Kpn colonization over the control was the length of hospital stay (odds ratio=1.062; P=0.019). Routine use of ASC could help control endemic ESBL–Kpn for ICU patients.
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참고문헌 (20)
참고문헌 신청
Zahar JR / 2019 / Screening for intestinal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in critically ill patients : expected benefits and evidence-based controversies / Clin Infect Dis 68:2125~2130
Lee Y / 2014 / Recent trends in antimicrobial resistance in intensive care units in Korea / Korean J Nosocomial Infect Control 19:29~36
Lee H / 2018 / Antimicrobial resistance of major clinical pathogens in South Korea, May 2016 to April 2017: first one-year report from Kor-GLASS / Euro Surveill 23:1800047
Muto CA / 2003 / SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus / Infect Control Hosp Epidemiol 24:362~386
Thouverez M / 2004 / Control of Enterobacteriaceae producing extended-spectrum beta-lactamase in intensive care units : rectal screening may not be needed in non-epidemic situations / Infect Control Hosp Epidemiol 25:838~841
Lee Y / 2014 / Recent trends in antimicrobial resistance in intensive care units in Korea / Korean J Nosocomial Infect Control 19:29~36
Lee H / 2018 / Antimicrobial resistance of major clinical pathogens in South Korea, May 2016 to April 2017: first one-year report from Kor-GLASS / Euro Surveill 23:1800047
Muto CA / 2003 / SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus / Infect Control Hosp Epidemiol 24:362~386
Thouverez M / 2004 / Control of Enterobacteriaceae producing extended-spectrum beta-lactamase in intensive care units : rectal screening may not be needed in non-epidemic situations / Infect Control Hosp Epidemiol 25:838~841
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