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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국센서학회 센서학회지 센서학회지 제29권 제2호
발행연도
2020.1
수록면
100 - 104 (5page)

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Thus far, several in vivo biosensing platforms have been proposed to measure the mechanical contractility of cultured cardiomyocytes. However, the low sensitivity and screening rate of the developed sensors severely limit their practical applications. In addition, intensive research and development in cardiovascular disease demand a high-throughput drug-screeningplatform based on biomimetic engineering. To overcome the drawbacks of the current state-of-the-art methods, we propose ahigh-throughput drug-screening platform based on 16 functional high-sensitivity well plates. The proposed system simulates thephysiological accuracy of the heart function in an in vitro environment. We fabricated 64 cantilevers using highly flexible andoptically transparent silicone rubber and placed in 16 independent wells. Nanogrooves were imprinted on the surface of the cantileverto promote cell alignment and maturation. The adverse effects of the cardiovascular drugs on the cultured cardiomyocyteswere systematically investigated. The 64 cantilevers demonstrated a highly reliable and reproducible mechanicalcontractility of the drug-treated cardiomyocytes. Real-time high-throughput screening and simultaneous evaluation of the cardiomyocytemechanical contractility under multiple drugs verified that the proposed system could be used as an efficient drugtoxicitytest platform.

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