지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Thus far, several in vivo biosensing platforms have been proposed to measure the mechanical contractility of cultured cardiomyocytes. However, the low sensitivity and screening rate of the developed sensors severely limit their practical applications. In addition, intensive research and development in cardiovascular disease demand a high-throughput drug-screeningplatform based on biomimetic engineering. To overcome the drawbacks of the current state-of-the-art methods, we propose ahigh-throughput drug-screening platform based on 16 functional high-sensitivity well plates. The proposed system simulates thephysiological accuracy of the heart function in an in vitro environment. We fabricated 64 cantilevers using highly flexible andoptically transparent silicone rubber and placed in 16 independent wells. Nanogrooves were imprinted on the surface of the cantileverto promote cell alignment and maturation. The adverse effects of the cardiovascular drugs on the cultured cardiomyocyteswere systematically investigated. The 64 cantilevers demonstrated a highly reliable and reproducible mechanicalcontractility of the drug-treated cardiomyocytes. Real-time high-throughput screening and simultaneous evaluation of the cardiomyocytemechanical contractility under multiple drugs verified that the proposed system could be used as an efficient drugtoxicitytest platform.
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
J. G. Jacot / 2010 / Cardiac myocyte force development during differentiation and maturation / Ann. N. Y. Acad. Sci 1188:121~127
K. S. Bielawski / 2016 / Real-time force and frequency analysis of engineered human heart tissue derived from induced pluripotent stem cells using magnetic sensing / Tissue Eng., Part C 22(10):932~940
I. Mannhardt / 2019 / Piezo?bending actuators for isometric or auxotonic contraction analysis of engineered heart tissue / J. Tissue Eng. Regener. Med 13(1):3~11
J. L. Tan / 2003 / Cells lying on a bed of microneedles : An approach to isolate mechanical force / Proc. Natl. Acad. Sci 100(4):1484~1489
R. E. Taylor / 2013 / Sacrificial layer technique for axial force post assay of immature cardiomyocytes / Biomed. Microdevices 15(1):171~181
K. S. Bielawski / 2016 / Real-time force and frequency analysis of engineered human heart tissue derived from induced pluripotent stem cells using magnetic sensing / Tissue Eng., Part C 22(10):932~940
I. Mannhardt / 2019 / Piezo?bending actuators for isometric or auxotonic contraction analysis of engineered heart tissue / J. Tissue Eng. Regener. Med 13(1):3~11
J. L. Tan / 2003 / Cells lying on a bed of microneedles : An approach to isolate mechanical force / Proc. Natl. Acad. Sci 100(4):1484~1489
R. E. Taylor / 2013 / Sacrificial layer technique for axial force post assay of immature cardiomyocytes / Biomed. Microdevices 15(1):171~181
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Polymer Cantilever Arrays Integrated with a Piezoresistive Strain Sensor based on Doped Silicon
한국정밀공학회 학술발표대회 논문집
2021 .11
-
캔틸레버 센서를 이용한 심장 근육 세포의 수축력 측정
한국정밀공학회 학술발표대회 논문집
2015 .05
-
심장 약물 독성 검사의 High Throughput 스크리닝을 위한 기능성 Well Plate 플랫폼
한국정밀공학회 학술발표대회 논문집
2017 .12
-
Analysis of the Growth Characteristics of Cardiac Cells According to Mechanical Properties of Substrates Using the Simplified Measurement Technique of Tracker
센서학회지
2022 .01
-
A novel approach for high-throughput co-culture and analysis of drug efficacy
대한기계학회 춘추학술대회
2022 .04
-
A Deep Learning Method for Prediction of Drug-Drug and Drug-Food Interactions
한국생물공학회 학술대회
2019 .10
-
Functional Cantilever-based Drug Toxicity Screening Platform for Electro-mechanophysiological Analysis of Cardiomyocytes
한국정밀공학회 학술발표대회 논문집
2023 .05
-
약물 정보 문서 임베딩을 이용한 딥러닝 기반 약물 간 상호작용 예측
한국정보통신학회 종합학술대회 논문집
2022 .05
-
Prediction of drug-drug and drug-food interactions using deep learning methods
한국생물공학회 학술대회
2018 .10
-
약물 반응에 따른 심근세포의 수축력과 심장박동과 관련한 이온과의 상호관계에 관한 연구
한국정밀공학회 학술발표대회 논문집
2016 .05
-
병렬화를 이용한 고효율 가상 약물 스크리닝
한국정보과학회 학술발표논문집
2022 .06
-
심근세포 성숙도 및 수축력 향상을 위한 AgNW 기반의 기능성 폴리머 캔틸레버
센서학회지
2021 .01
-
Deep Learning Enables Prediction of Drug-drug and Drug-food Interactions
한국생물공학회 학술대회
2020 .06
-
Antimicrobial Drug Screening Using a Whole Animal Infection Model
한국생물공학회 학술대회
2020 .10
-
A SU-8 Cantilever Integrated with Microelectrode arrays for Real Time Drug-induced Cardiac Toxicity Screening
한국정밀공학회 학술발표대회 논문집
2016 .10
-
Ex vivo Drug Sensitivity Tests of Drug Combinations in Non-Hodgkin Lymphoma
한국생물공학회 학술대회
2024 .09
-
AgNW-loaded PDMS Thin Film for Improving Adhesion and Maturation of Cardiomyocytes
한국정밀공학회 학술발표대회 논문집
2021 .05
-
Analysis of Synergy Between Rabacfosadine and Chemotherapeutic Drugs Based on ex vivo Drug Sensitivity Assaying
한국생물공학회 학술대회
2024 .09
-
펨토초 레이저 가공을 이용한 3차원 약물 검사 시스템 구현
대한기계학회 춘추학술대회
2017 .11
-
Patient Drug Database: 환자 생성 건강 데이터를 활용한 환자 주도적 약물 부작용 탐색을 위한 데이터베이스 구축
보건정보통계학회지
2021 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0