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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 309 - 3,016 (2708page)
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In this study, we investigated the protective effects of Ulva lactuca methanol extracts against ultraviolet B (UVB)-induced DNA damage in HaCaT cells. First, the contents of general and antioxidative nutrient contents of Ulva lactuca were measured. The moisture, carbohydrate, crude protein, crude fat and ash were 14.01%, 44.80%, 23.19%, 3.10% and 14.90%, respectively. Magnesium that acts as DNA repair enzyme cofactor was the most abundant mineral followed by Ca, P and Fe. The total phenolic and anthocyanoside contents of Ulva lactuca were 2.69 mg/g and 0.13 mg/g, respectively. Cells treated with Ulva lactuca methanol extracts for 24 hours post UVB exposure increased cell viability in a concentration-dependent manner compared to the non-treated control. Also, Ulva lactuca methanol extracts decreased the levels of UVB-induced DNA damage such as cyclobutane pyrimidine dimer and DNA damage response (DDR) proteins such as p-p53 and p21. These results suggest that Ulva lactuca methanol extracts comprising physiological active substances such as Mg, polyphenols and anthocyanosides promote DNA repair by regulating genes related with DDR. Key words: Ulva lactuca, ultraviolet B, DNA damage
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참고문헌 (34)
참고문헌 신청
Abd EI Baky HH / 2016 / Potential of macroalgae Ulva lactuca as a source feedstock for biodiesel production / Recent Pat Food Nutr Agric 8:199~204
Abd-Ellatef GF / 2017 / Ulva lactuca polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation / Breast Cancer 9:67~83
Abhishek D / 2018 / Pharmacognostic standardization of Chaetomorpha antennina and Ulva lactuca, green seaweeds from Gujarat coast / J Pharmacogn Phytochem 7:3863~3870
Abirami RG / 2011 / Nutrient and nutraceutical potentials of seaweed biomass Ulva lactuca and Kappaphycus alvarezii / J Agric Sci Technol 5:109~115
Adhikari S / 2006 / Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase / J Biol Chem 281:29525~29532
Abd-Ellatef GF / 2017 / Ulva lactuca polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation / Breast Cancer 9:67~83
Abhishek D / 2018 / Pharmacognostic standardization of Chaetomorpha antennina and Ulva lactuca, green seaweeds from Gujarat coast / J Pharmacogn Phytochem 7:3863~3870
Abirami RG / 2011 / Nutrient and nutraceutical potentials of seaweed biomass Ulva lactuca and Kappaphycus alvarezii / J Agric Sci Technol 5:109~115
Adhikari S / 2006 / Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase / J Biol Chem 281:29525~29532
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