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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제1호
- 발행연도
- 2020.1
- 수록면
- 1 - 16 (16page)
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Vitamin D is involved in retaining the balance of several minerals in the body, such as calcium and phosphate, which are crucial for the bone formation and development. These physiological effects of vitamin D are mediated by activation of the transcription factor vitamin D receptor (VDR). Moreover, vitamin D is closely related to several pathological conditions including osteoporosis, secondary hyperparathyroidism, cancer, psoriasis and autoimmune diseases, which is not only due to calcemic but also non-calcemic effects of vitamin D such as cell proliferation, differentiation, and immunomodulation. These various abilities of vitamin D have made VDR an attractive therapeutic target. Already, numerous vitamin D analogs have been developed and studied in in vitro disease models or animal models, and some have been in clinical trials or approved for the treatment of certain diseases. In addition, the transcriptional and/or post-transcriptional regulation by VDR activation also affects the genes involved in drug metabolism and disposition, possibly leading to pharmacokinetic changes of several drugs in clinical use. This review provides a detailed summary of therapeutic targets of VDR ligands, and their effects on the transporters and metabolic enzymes, causing in vitro and in vivo pharmacokinetic changes of several drugs. The clinical research is further required for the confirming the clinical relevance of pharmacokinetic drug interactions by VDR ligands.
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참고문헌 (174)
참고문헌 신청
Abou-Raya A / 2013 / The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus : a randomized placebo-controlled trial / J Rheumatol 40:265~272
Adami S / 2009 / Vitamin D status and response to treatment in post-menopausal osteoporosis / Osteoporos Int 20:239~244
Aguilera O / 2007 / The Wnt antagonist DICKKOPF-1 gene is induced by 1α, 25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells / Carcinogenesis 28:1877~1884
Åivo J / 2015 / Vitamin D3administration to MS patients leads to increased serum levels of latency activated peptide(LAP)of TGF-beta / J Neuroimmunol 280:12~15
Akizawa T / 2002 / Long-term effect of 1,25-dihydroxy-22-oxavitamin D(3) on secondary hyperparathyroidism in haemodialysis patients. One-year administration study / Nephrol Dial Transplant 17(Suppl. 10):28~36
Adami S / 2009 / Vitamin D status and response to treatment in post-menopausal osteoporosis / Osteoporos Int 20:239~244
Aguilera O / 2007 / The Wnt antagonist DICKKOPF-1 gene is induced by 1α, 25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells / Carcinogenesis 28:1877~1884
Åivo J / 2015 / Vitamin D3administration to MS patients leads to increased serum levels of latency activated peptide(LAP)of TGF-beta / J Neuroimmunol 280:12~15
Akizawa T / 2002 / Long-term effect of 1,25-dihydroxy-22-oxavitamin D(3) on secondary hyperparathyroidism in haemodialysis patients. One-year administration study / Nephrol Dial Transplant 17(Suppl. 10):28~36
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