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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제2호
- 발행연도
- 2020.1
- 수록면
- 131 - 145 (15page)
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초록· 키워드
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Background Three-dimensional (3D) printing is a process for creating 3D objects with various geometries using digital modeling, and it is widely used in the construction and medical industries. In the field of pharmacy, 3D printers were introduced as a suitable manufacturing method in response to the increasing need for “personalization.” Since the first 3D printed drug, Spritam ®, was approved by the Food and Drug Administration (FDA) in 2015, 3D printer technology has evolved through considerable research. The 3D printing methods are classified into selective laser sintering, inkjet printing, stereolithography, digital light processing, and fused deposition modeling (FDM) according to the printing method. Among them, FDM, which is a method of extruding filaments through a nozzle, is the most widely used 3D printer method in pharmaceuticals. Area covered This review paper covers the detail content of manufacturing drugs by FDM. Owing to its ease of use and relatively low price, many studies have focused on FDM 3D printers. In this review paper, we concretely investigate a series of FDM procedures and parameters and introduce many studies that used FDM 3D printers to control the release, to make novel dosage form, and to deliver the customized doses. Expert opinion FDM is completely different from traditional drug manufacturing methods, and it is expected to achieve personalization. Once mechanical problems and regulatory barriers are overcome and new developments are made, FDM 3D printers will become a unique and effective way to manufacture patient-customized drugs in the pharmaceutical industry.
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참고문헌 (78)
참고문헌 신청
Abuzar SM / 2018 / Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent(SAS)process / Int J Pharm 538:1~13
Alhijjaj M / 2016 / An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling(FDM)3D printing / Eur J Pharm Biopharm 108:111~125
Al-Metwali B / 2017 / Personalised dosing of medicines for children / J Pharm Pharmacol 69:514~524
Anitha R / 2001 / Critical parameters influencing the quality of prototypes in fused deposition modelling / J Mater Process Technol 118:385~388
Arafat B / 2018 / Tailored on demand anti-coagulant dosing : an in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms / Eur J Pharm Biopharm 128:282~289
Alhijjaj M / 2016 / An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling(FDM)3D printing / Eur J Pharm Biopharm 108:111~125
Al-Metwali B / 2017 / Personalised dosing of medicines for children / J Pharm Pharmacol 69:514~524
Anitha R / 2001 / Critical parameters influencing the quality of prototypes in fused deposition modelling / J Mater Process Technol 118:385~388
Arafat B / 2018 / Tailored on demand anti-coagulant dosing : an in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms / Eur J Pharm Biopharm 128:282~289
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