지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: We evaluated the effects of adding intravenous pamidronate to ongoing menopausal hormone therapy (MHT) on bone mineral density (BMD) in postmenopausal Korean women with low BMD. Methods: This retrospective cohort study included 74 postmenopausal women who received MHT for at least 1 year and had a BMD T-score of less than −2.0. Maintaining the same MHT regimen, these women were divided into two groups: oral placebo group (n = 44) and a pamidronate group of patients with gastrointestinal discomfort (n = 30) who received 15–30 mg pamidronate intravenously every 3–12 months. BMD was reviewed at 12-month follow-up. Bone resorption markers in both groups, urinary deoxypyridinoline levels in the placebo group, and serum N-telopeptide of type I collagen in the pamidronate group were assessed at 6 and 12 months. Results: At baseline, the body mass index (BMI), duration of previous MHT, and femur neck (FN) BMD differed between the groups. Within-group analysis revealed that BMD of the lumbar spine (LS) and total hip (TH) significantly increased in the placebo group, whereas those of the LS, FN, and TH increased in the pamidronate group. The increase in BMD of LS was significantly greater in the pamidronate group, after adjusting for BMI and duration of previous MHT (mean change: 3.7% vs. 6.2%; P < 0.001). There were no changes in bone resorption markers in either group. Conclusions: Adding intravenous pamidronate to ongoing MHT for 12 months might increase LS BMD in postmenopausal Korean women with low BMD.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
The Writing Group for the PEPI / 1996 / Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial / JAMA 276:1389~1396
Nelson HD / 2002 / Osteoporosis and fractures in postmenopausal women using estrogen / Arch Intern Med 162:2278~2284
Hillard TC / 1994 / Long-term effects of transdermal and oral hormone replacement therapy on postmenopausal bone loss / Osteoporos Int 4:341~348
Fleisch H / 1998 / Bisphosphonates : mechanisms of action / Endocr Rev 19:80~100
Black DM / 1996 / Fracture Intervention Trial Research Group / Lancet 348:1535~1541
Nelson HD / 2002 / Osteoporosis and fractures in postmenopausal women using estrogen / Arch Intern Med 162:2278~2284
Hillard TC / 1994 / Long-term effects of transdermal and oral hormone replacement therapy on postmenopausal bone loss / Osteoporos Int 4:341~348
Fleisch H / 1998 / Bisphosphonates : mechanisms of action / Endocr Rev 19:80~100
Black DM / 1996 / Fracture Intervention Trial Research Group / Lancet 348:1535~1541
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