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Background: The electrochemical biosensor is one of the typical sensing devices based on transducing the biochemical events to electrical signals. In this type of sensor, an electrode is a key component that is employed as a solid support for immobilization of biomolecules and electron movement. Thanks to numerous nanomaterials that possess the large surface area, synergic effects are enabled by improving loading capacity and the mass transport of reactants for achieving high performance in terms of analytical sensitivity. Main body: We categorized the current electrochemical biosensors into two groups, carbon-based (carbon nanotubes and graphene) and non-carbon-based nanomaterials (metallic and silica nanoparticles, nanowire, and indium tin oxide, organic materials). The carbon allotropes can be employed as an electrode and supporting scaffolds due to their large active surface area as well as an effective electron transfer rate. We also discussed the non-carbon nanomaterials that are used as alternative supporting components of the electrode for improving the electrochemical properties of biosensors. Conclusion: Although several functional nanomaterials have provided the innovative solid substrate for high performances, developing on-site version of biosensor that meets enough sensitivity along with high reproducibility still remains a challenge. In particular, the matrix interference from real samples which seriously affects the biomolecular interaction still remains the most critical issues that need to be solved for practical aspect in the electrochemical biosensor.
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참고문헌 (128)
참고문헌 신청
Li H / 2016 / CMOS electrochemical instrumentation for biosensor microsystems : a review / Sensors 17:74
Zheng H / 2013 / Label-free electrochemical impedance biosensor for sequence-specific recognition of double-stranded DNA / Anal Methods 5:5005~5009
Clark LC Jr / 1962 / Electrode systems for continuous monitoring in cardiovascular surgery / Ann N Y Acad Sci 102:29~45
Wang Z / 2015 / Carbon nanomaterial-based electrochemical biosensors : an overview / Nanoscale 7:6420~6431
Krishnan SK / 2019 / A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors / RSC Adv 9:8778~8881
Zheng H / 2013 / Label-free electrochemical impedance biosensor for sequence-specific recognition of double-stranded DNA / Anal Methods 5:5005~5009
Clark LC Jr / 1962 / Electrode systems for continuous monitoring in cardiovascular surgery / Ann N Y Acad Sci 102:29~45
Wang Z / 2015 / Carbon nanomaterial-based electrochemical biosensors : an overview / Nanoscale 7:6420~6431
Krishnan SK / 2019 / A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors / RSC Adv 9:8778~8881
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