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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,117 - 1,128 (12page)
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Cancer remains to be a major challenge for public health providers, and is the second leading cause of death worldwide. Therefore,it is imperative to explore the mechanisms underlying cancer initiation and development, and design novel diagnostics andtherapeutics. Circular RNAs (circRNAs), which exhibit a covalently closed loop structure, are involved in a variety of diseases, includingcancer. The aberrant expression of circRNAs contributes to the initiation and development of various cancers by disruptingthe interplay of specific signaling pathways, including the Wnt/β-catenin pathway, which controls a plethora of cellular processesthat drive cancer development. The interactions between circRNAs (specifically expressed in different cancer tissues) andWnt/β-catenin signaling pathway presents potential diagnostic biomarkers and novel therapeutic targets. In this review, we havesummarized research discoveries on the functions of Wnt/β-catenin pathway-related circRNAs in the modulation of oncogenesisand progression of different types of cancer. We anticipate that our findings will contribute to the improvement or developmentof circRNAs-based strategies for cancer treatment.
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참고문헌 (97)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Lu D / 2017 / lncRNA PVT1 in cancer : a review and meta-analysis / Clin Chim Acta 474:1~7
Cech TR / 2014 / The noncoding RNA revolution-trashing old rules to forge new ones / Cell 157:77~94
Hu X / 2014 / A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer / Cancer Cell 26:344~357
Chen W / 2016 / Cancer statistics in China, 2015 / CA Cancer J Clin 66:115~132
Lu D / 2017 / lncRNA PVT1 in cancer : a review and meta-analysis / Clin Chim Acta 474:1~7
Cech TR / 2014 / The noncoding RNA revolution-trashing old rules to forge new ones / Cell 157:77~94
Hu X / 2014 / A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer / Cancer Cell 26:344~357
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EGCG Inhibits Growth of MDA-MB-231 Breast Cancer Cell through the Inactivation of B Catenin Signaling Pathway
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