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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제18권 제4호
- 발행연도
- 2019.1
- 수록면
- 113 - 121 (9page)
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초록· 키워드
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Background and Purpose: Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in cortical thinning patterns among patients with SCD who progressed to mild cognitive impairment or dementia (pSCD), those who remained stable (sSCD), and healthy normal controls (NCs). Methods: We retrospectively recruited SCD subjects (14 pSCD and 21 sSCD cases) and 29 NCs. Structural 3-dimensional-T1-weighted magnetic resonance imaging was performed using a single 1.5 Tesla scanner. Freesurfer software was used to map cortical thickness for group comparisons. Results: Compared with NC group, the sSCD group showed diffuse cortical atrophy associated with bilateral fronto-parieto-temporal area. The pSCD group showed further characteristic cortical atrophy in AD-vulnerable regions including the inferior parietotemporal and middle temporal areas. Cortical thinning in the bilateral medial frontal areas was observed in patients with sSCD and involved the right inferior temporal and left precentral areas in those with pSCD. Conclusions: Our study showed that SCD subjects exhibit different cortical thinning patterns depending on their prognosis.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Jessen F / 2014 / A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease / Alzheimers Dement 10:844~852
Jack CR Jr / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade / Lancet Neurol 9:119~128
Visser PJ / 2009 / Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study / Lancet Neurol 8:619~627
Amariglio RE / 2012 / Subjective cognitive complaints and amyloid burden in cognitively normal older individuals / Neuropsychologia 50:2880~2886
van Harten AC / 2013 / Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints / Alzheimers Dement 9:481~487
Jack CR Jr / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade / Lancet Neurol 9:119~128
Visser PJ / 2009 / Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study / Lancet Neurol 8:619~627
Amariglio RE / 2012 / Subjective cognitive complaints and amyloid burden in cognitively normal older individuals / Neuropsychologia 50:2880~2886
van Harten AC / 2013 / Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints / Alzheimers Dement 9:481~487
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