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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 51 - 56 (6page)
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Purpose: Periventricular leukomalacia (PVL) is an important morbidity in preterm infants. Its reported prevalence in very low birth weight (VLBW) infants is 3% to 15% in VLBW infants. PVL develop seizure disorder, intellectual disability, visual problem, and cerebral palsy. This study was done to describe the risk factors of PVL in VLBW infants. Methods: Medical records of 172 VLBW infants at Inje University Ilsan Paik Hospital neonatal intensive care unit were reviewed retrospectively from January 2010 to December 2014. Patients were divided into the non-PVL group (n=155) and the PVL group (n=17). The PVL group included both cystic and non-cystic forms. Demographic findings and factors associated with PVL were compared between these groups. Results: The incidence of non-cystic and cystic PVL was 9.8%. The mean gestational age was significantly lower in the PVL group. The mean birth weight was not significantly different between the groups. The incidences of premature rupture of membrane and pregnancy induced hypertension were not significantly different between the two groups. The number of histologic chorioamnionitis was significantly higher in the PVL group (P<0.05). Other conditions such as respiratory distress syndrome, patent ductus arteriosus, early-onset sepsis, and hypotension were not significantly different between the two groups. The incidence of intravascular hemorrhage (IVH) (grade ≥3) was more significant in the PVL group (P<0.05). Multiple logistic regression analysis indicated that histologic chorioamnionitis (odds ratio [OR], 6.3; 95% confidence interval [CI], 1.1 to 36.3) and IVH (grade ≥3) (OR, 16.9; 95% CI, 1.9 to 153.1) were significant risk factors of PVL. Conclusion: Histologic chorioamnionitis and IVH (grade ≥3) increase the risk of PVL in VLBW infants. Strategies to prevent these conditions could attenuate the incidence of PVL.
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참고문헌 (20)
참고문헌 신청
Khwaja O / 2008 / Pathogenesis of cerebral white matter injury of prematurity / Arch Dis Child Fetal Neonatal Ed 93:F153~F161
Blumenthal I / 2004 / Periventricular leucomalacia : a review / Eur J Pediatr 163:435~442
Kusters CD / 2009 / ''Intraventri cular'' hemorrhage and cystic periventricular leukomalacia in preterm infants: how are they related? / J Child Neurol 24:1158~1170
Rocha G / 2007 / Chorioamnionitis and brain damage in the preterm newborn / J Matern Fetal Neonatal Med 20:745~749
Herzog M / 2015 / Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study / Eur J Obstet Gynecol Reprod Biol 187:57~59
Blumenthal I / 2004 / Periventricular leucomalacia : a review / Eur J Pediatr 163:435~442
Kusters CD / 2009 / ''Intraventri cular'' hemorrhage and cystic periventricular leukomalacia in preterm infants: how are they related? / J Child Neurol 24:1158~1170
Rocha G / 2007 / Chorioamnionitis and brain damage in the preterm newborn / J Matern Fetal Neonatal Med 20:745~749
Herzog M / 2015 / Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study / Eur J Obstet Gynecol Reprod Biol 187:57~59
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