Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer

Davide Melisi; Valeria Merz; Simona Casalino; Camilla Zecchetto; Francesca Simionato; Hayley Louise Salt; Serena Contarelli; Raffaela Santoro

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자료유형: 학술저널

저자정보: Davide Melisi Valeria Merz Simona Casalino Camilla Zecchetto Francesca Simionato Hayley Louise Salt Serena Contarelli Raffaela Santoro

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제19권 제4호

발행연도: 2019.1

수록면: 375 - 392 (18page)

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Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and esophagogastric junction cancer in Western countries. However, in a large number of cases, the tumor is extremely resistant to these treatments and the patients are exposed to unnecessary toxicity and delayed surgical therapy. The current clinical trials evaluating the combination of preoperative systemic therapies with modern targeted and immunotherapeutic agents represent a unique opportunity for identifying predictive biomarkers of response to select patients that would benefit the most from these treatments. However, it is of utmost importance that these potential biomarkers are corroborated by extensive preclinical and translational research. The aim of this review article is to present the most promising biomarkers of response to classic chemotherapeutic, anti-HER2, antiangiogenic, and immunotherapeutic agents that can be potentially useful for personalized preoperative systemic therapies in gastric cancer patients.

참고문헌 (100)

참고문헌 신청

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