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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 60 - 71 (12page)
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The utility of 18-fluordesoxyglucose positron emission tomography ([18F]-FDG-PET) combined with computer tomography or magnetic resonance imaging (MRI) in gastric cancer remains controversial and a rationale for patient selection is desired. This study aims to establish a preclinical patient-derived xenograft (PDX) based [18F]-FDG-PET/MRI protocol for gastric cancer and compare different PDX models regarding tumor growth and FDG uptake. Materials and Methods Female BALB/c nu/nu mice were implanted orthotopically and subcutaneously with gastric cancer PDX. [18F]-FDG-PET/MRI scanning protocol evaluation included different tumor sizes, FDG doses, scanning intervals, and organ-specific uptake. FDG avidity of similar PDX cases were compared between ortho- and heterotopic tumor implantation methods. Microscopic and immunohistochemical investigations were performed to confirm tumor growth and correlate the glycolysis markers glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) with FDG uptake. Results Organ-specific uptake analysis showed specific FDG avidity of the tumor tissue. Standard scanning protocol was determined to include 150 μCi FDG injection dose and scanning after one hour. Comparison of heterotopic and orthotopic implanted mice revealed a long growth interval for orthotopic models with a high uptake in similar PDX tissues. The H-score of GLUT1 and HK2 expression in tumor cells correlated with the measured maximal standardized uptake value values (GLUT1: Pearson r=0.743, P=0.009; HK2: Pearson r=0.605, P=0.049). Conclusions This preclinical gastric cancer PDX based [18F]-FDG-PET/MRI protocol reveals tumor specific FDG uptake and shows correlation to glucose metabolic proteins. Our findings provide a PET/MRI PDX model that can be applicable for translational gastric cancer research.
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참고문헌 (29)
참고문헌 신청
Gullo I / 2018 / Heterogeneity in gastric cancer : from pure morphology to molecular classifications / Pathobiology 85:50~63
Schlößer HA / 2017 / Glucose transporters 1, 3, 6, and 10 are expressed in gastric cancer and glucose transporter 3 is associated with UICC stage and survival / Gastric Cancer 20:83~91
Berlth F / 2014 / Validation of 2-mm tissue microarray technology in gastric cancer. Agreement of 2-mm TMAs and full sections for GLUT-1 and HIF-1 alpha / Anticancer Res 34:3313~3320
Alakus H / 2010 / Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression / Nucl Med Commun 31:532~538
Berlth F / 2015 / Both GLUT-1 and GLUT-14 are independent prognostic factors in gastric adenocarcinoma / Ann Surg Oncol 22(Suppl 3):S822~S831
Schlößer HA / 2017 / Glucose transporters 1, 3, 6, and 10 are expressed in gastric cancer and glucose transporter 3 is associated with UICC stage and survival / Gastric Cancer 20:83~91
Berlth F / 2014 / Validation of 2-mm tissue microarray technology in gastric cancer. Agreement of 2-mm TMAs and full sections for GLUT-1 and HIF-1 alpha / Anticancer Res 34:3313~3320
Alakus H / 2010 / Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression / Nucl Med Commun 31:532~538
Berlth F / 2015 / Both GLUT-1 and GLUT-14 are independent prognostic factors in gastric adenocarcinoma / Ann Surg Oncol 22(Suppl 3):S822~S831
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