지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 115 - 126 (12page)
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초록· 키워드
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Peritoneal metastasis (PM) frequently occurs in patients with gastric cancer (GC) and confers a dismal prognosis despite advances in systemic chemotherapy. While systemic chemotherapy has poor peritoneal penetration, intraperitoneal (IP) chemotherapy remains sequestered, resulting in high peritoneal drug concentrations with less systemic side-effects. The first application of IP treatment was hyperthermic intraperitoneal chemotherapy (HIPEC) with cytoreductive surgery (CRS) for gastric cancer peritoneal metastasis (GCPM); but was associated with an increased morbidity and mortality rate without significantly improving overall survival (OS). While CRS confers limited benefit, the potential role of prophylactic HIPEC and laparoscopic neoadjuvant HIPEC are currently being evaluated. Combination systemic and IP chemotherapy (SIPC) gained popularity in the 1990s, since it provided the benefits of IP treatment while reducing surgical morbidity, demonstrating promising early results in multiple Phase II trials. Unfortunately, these findings were not confirmed in the recent PHOENIX-GC randomized controlled trial; therefore, the appropriate treatment for GCPM remains controversial. Small observational studies from Japan and Singapore have reported successful downstaging of PM in GC patients receiving SIPC who subsequently underwent conversion gastrectomy with a median OS of 21.6–34.6 months. Recently, the most significant development in IP-directed therapy is pressurized IP aerosol chemotherapy (PIPAC). Given that aerosol chemotherapy achieves a wider distribution and deeper penetration, the outcomes of multiple ongoing trials assessing its efficacy are eagerly awaited. Indeed, IP-directed therapy has evolved rapidly in the last 3 decades, with an encouraging trend toward improved outcomes in GCPM, and may offer some hope for an otherwise fatal disease.
목차
등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Jacquet P / 1996 / Peritoneal-plasma barrier / Cancer Treat Res 82:53~63
Yonemura Y / 2016 / A comprehensive treatment for peritoneal metastases from gastric cancer with curative intent / Eur J Surg Oncol 42:1123~1131
Sadeghi B / 2000 / Peritoneal carcinomatosis from non-gynecologic malignancies : results of the EVOCAPE 1 multicentric prospective study / Cancer 88:358~363
Chu DZ / 1989 / Peritoneal carcinomatosis in nongynecologic malignancy. A prospective study of prognostic factors / Cancer 63:364~367
Shirao K / 2013 / Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis(JCOG0106) / Jpn J Clin Oncol 43:972~980
Yonemura Y / 2016 / A comprehensive treatment for peritoneal metastases from gastric cancer with curative intent / Eur J Surg Oncol 42:1123~1131
Sadeghi B / 2000 / Peritoneal carcinomatosis from non-gynecologic malignancies : results of the EVOCAPE 1 multicentric prospective study / Cancer 88:358~363
Chu DZ / 1989 / Peritoneal carcinomatosis in nongynecologic malignancy. A prospective study of prognostic factors / Cancer 63:364~367
Shirao K / 2013 / Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis(JCOG0106) / Jpn J Clin Oncol 43:972~980
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