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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 306 - 315 (10page)
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Mesenchymal stem cell transplantation is an emerging therapy for treating chronic liver diseases. The potential of this treatment has been evaluated in preclinical and clinical studies. Although the mechanisms of mesenchymal stem cell transplantation are still not completely understood, accumulating evidence has revealed that their immunomodulation, differentiation, and antifibrotic properties play a crucial role in liver regeneration. The safety and therapeutic effects of mesenchymal stem cells in patients with chronic liver disease have been observed in many clinical studies. However, only modest improvements have been seen, partly because of the limited feasibility of transplanted cells at present. Here, we discuss several strategies targeted at improving viable cell engraftment and the potential challenges in the use of extracellular vesicle-based therapies for liver disease in the future.
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참고문헌 (89)
참고문헌 신청
Kwang Yong Shim / 2018 / Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension / The Korean Journal of Internal Medicine 33(3):453~461
김가은 / 2017 / Transient elastography versus hepatic venous pressure gradient for diagnosing portal hypertension: a systematic review and meta-analysis / Clinical and Molecular Hepatology 23(1):34~41
Kang SH / 2018 / Novelties in the pathophysiology and management of portal hypertension : new treatments on the horizon / Hepatol Int 12:112~121
Si-Tayeb K / 2010 / Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells / Hepatology 51:297~305
Shu SN / 2004 / Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells / World J Gastroenterol 10:2818~2822
김가은 / 2017 / Transient elastography versus hepatic venous pressure gradient for diagnosing portal hypertension: a systematic review and meta-analysis / Clinical and Molecular Hepatology 23(1):34~41
Kang SH / 2018 / Novelties in the pathophysiology and management of portal hypertension : new treatments on the horizon / Hepatol Int 12:112~121
Si-Tayeb K / 2010 / Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells / Hepatology 51:297~305
Shu SN / 2004 / Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells / World J Gastroenterol 10:2818~2822
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Current and Future Perspectives of Stem Cell Therapy in Dermatology
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Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
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Current Concepts in Stem Cell Therapy for Cardiovascular Diseases: What We Know and Don’t Know
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Recent advances in stem cell therapeutics and tissue engineering strategies
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Clinical Trials of Adult Stem Cell Terapy in Patients with Ischemic Stroke
Journal of Clinical Neurology
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Study on Patients without Underlying Chronic Liver Disease to Improve Survival Outcome in Pediatric Liver Transplantation
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