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Treatment Outcomes and Prognostic Factors of Acute Variceal Bleeding in Patients with Hepatocellular Carcinoma
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논문 기본 정보

Type
Academic journal
Author
Journal
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제14권 제4호 KCI Accredited Journals SCOPUS
Published
2020.1
Pages
500 - 508 (9page)

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Treatment Outcomes and Prognostic Factors of Acute Variceal Bleeding in Patients with Hepatocellular Carcinoma
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Background/Aims: The treatment outcomes and prognostic markers of acute variceal bleeding (AVB) in hepatocellular carcinoma (HCC) patients remain unclear. Therefore, we evaluated the clinical outcomes and prognostic factors of AVB in HCC patients. Methods: Cirrhotic patients with endoscopically confirmed AVB between 2007 and 2013 were enrolled in this prospective study. Prognostic factors were identified by multivariate Cox proportional hazards regression analysis. Results: Among the 329 enrolled patients, 125 patients (38.0%) were diagnosed with HCC. The 6-week mortality rates of all enrolled AVB patients and the HCC subgroup were 14.9% and 26.4%. The 5-day treatment failure, 6-week mortality, cirrhosis-related complications, and duration of hospitalization were greater in HCC patients than in non-HCC patients (all p<0.05). In the HCC subgroup, the Model for End-Stage Liver Disease (MELD) score (hazard ratio [HR], 1.145; p=0.001) and Barcelona Clinic Liver Cancer (BCLC) stage (C–D vs 0–B) (HR, 3.096; p=0.019) were independent predictors of 6-week mortality. Our study revealed that 85% of HCC patients with both a MELD score ≥15.5 and BCLC stage C–D died within 6 weeks, and the 6-week mortality risk was 21-fold higher in this group than in the group with a lower MELD score and earlier HCC stage (p<0.001). Conclusions: The 5-day treatment failure and 6-week mortality rates were significantly higher among AVB patients with HCC than those without HCC. The MELD score and the presence and stage of HCC are strong predictors of 6-week mortality in patients with AVB.

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References (27)

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Graham DY / 1981 / The course of patients after variceal hemorrhage / Gastroenterology 80:800~809 google schola De Franchis R / 2010 / Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension / J Hepatol 53:762~768 google schola Chalasani N / 2003 / Improved patient survival after acute variceal bleeding : a multicenter, cohort study / Am J Gastroenterol 98:653~659 google schola Carbonell N / 2004 / Improved survival after variceal bleeding in patients with cirrhosis over the past two decades / Hepatology 40:652~659 google schola García-Pagán JC / 2010 / Early use of TIPS in patients with cirrhosis and variceal bleeding / N Engl J Med 362:2370~2379 google schola

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