지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 276 - 286 (11page)
- DOI
- 10.7783/KJMCS.2020.28.4.276
이용수
초록· 키워드
오류제보하기
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with multiple metabolic disorders. The medicinal plant Curcuma longa L. is widely distributed in Asia and has been used to treat a spectrum diseases in clinical practice. To date, there are inadequate reports of the effects of C. longa 50% EtOH extract (CE) on NAFLD. Therefore, in this study, we evaluate the CE on an NAFLD animal and elucidate the mechanism of action.
Methods and Results: C57BL/6J mice fed a methionine-choline deficient diet (MCD) were treated with CE or milk thistle, and changes in inflammation and stetosis were assessed. Experimental animals were divided into six group (n = 10); Normal, MCD, MCD + CE 50 ㎎/㎏/day (CE 50), MCD + CE 100 ㎎/㎏/day (CE 100), MCD + CE 150 ㎎/㎏/day (CE 150), and the Control, MCD + Milk thistle 150 ㎎/㎏/day (MT 150). Body weight, liver weight, liver function, and histological changes were assessed in experimental animals. Quantitative real-time polymerase chain reaction and western blot analyses were performed on samples collected after 4 weeks of treatment. We observed that CE administration improved MCD-diet-induced lipid accumulation, and triglyceride (TG) and total cholesterol (TC) levels in serum. Treatment with CE also decreased hepatic lipogenesis through modulation of the sterol regulatory element binding protein-1 (SREBP-1), CCAAT-enhancer binding protein α (C/EBPα), fatty acid synthase (FAS), and peroxisome proliferator-activated receptor γ (PPARγ) expresion. In addition, the use of CE increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and inhibited the up-regulation of toll-like receptor (TLR)-2 and TLR-4 signaling and the production of inflammatory mediators.
Conclusions: In this report, we observed that CE regulated lipid accumulation in an MCD diet-induced NAFLD model by decreasing lipogenesis. These data suggeste that CE could effectively protect mice against MCD-induced NAFLD, by inhibiting the TLR-2 and TLR-4 signaling cascades.
Methods and Results: C57BL/6J mice fed a methionine-choline deficient diet (MCD) were treated with CE or milk thistle, and changes in inflammation and stetosis were assessed. Experimental animals were divided into six group (n = 10); Normal, MCD, MCD + CE 50 ㎎/㎏/day (CE 50), MCD + CE 100 ㎎/㎏/day (CE 100), MCD + CE 150 ㎎/㎏/day (CE 150), and the Control, MCD + Milk thistle 150 ㎎/㎏/day (MT 150). Body weight, liver weight, liver function, and histological changes were assessed in experimental animals. Quantitative real-time polymerase chain reaction and western blot analyses were performed on samples collected after 4 weeks of treatment. We observed that CE administration improved MCD-diet-induced lipid accumulation, and triglyceride (TG) and total cholesterol (TC) levels in serum. Treatment with CE also decreased hepatic lipogenesis through modulation of the sterol regulatory element binding protein-1 (SREBP-1), CCAAT-enhancer binding protein α (C/EBPα), fatty acid synthase (FAS), and peroxisome proliferator-activated receptor γ (PPARγ) expresion. In addition, the use of CE increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and inhibited the up-regulation of toll-like receptor (TLR)-2 and TLR-4 signaling and the production of inflammatory mediators.
Conclusions: In this report, we observed that CE regulated lipid accumulation in an MCD diet-induced NAFLD model by decreasing lipogenesis. These data suggeste that CE could effectively protect mice against MCD-induced NAFLD, by inhibiting the TLR-2 and TLR-4 signaling cascades.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (33)
참고문헌 신청
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Akira S / 2004 / Toll-like receptor signalling / Nature Reviews Immunology 4:499~511
Ammon HP / 1991 / Pharmacology of Curcuma longa / Planta Medica 57:1~7
Arrese M / 2016 / Innate immunity and inflammation in NAFLD/NASH / Digestive Diseases and Sciences 61:1294~1303
Bacon BR / 1994 / Nonalcoholic steatohepatitis : An expanded clinical entity / Gastroenterology 107:1103~1109
Akira S / 2004 / Toll-like receptor signalling / Nature Reviews Immunology 4:499~511
Ammon HP / 1991 / Pharmacology of Curcuma longa / Planta Medica 57:1~7
Arrese M / 2016 / Innate immunity and inflammation in NAFLD/NASH / Digestive Diseases and Sciences 61:1294~1303
Bacon BR / 1994 / Nonalcoholic steatohepatitis : An expanded clinical entity / Gastroenterology 107:1103~1109
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UCI(KEPA) : I410-ECN-0101-2020-480-001160372