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논문 기본 정보

자료유형
학술저널
저자정보
강익원 (서울대학교 의과대학 방사선과학교실) 박찬일 (서울대학교 의과대학 방사선과학교실) 김주완 (서울대학교 의과대학 방사선과학교실)
저널정보
대한영상의학회 대한방사선의학회지 대한방사선의학회지 제17권 제2호
발행연도
1981.1
수록면
187 - 192 (6page)

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The effect of radiation on the liver should be of unusual in as much as there are two highly specialized kinds of epithelium besides and important endothelial system and vascular and fibrous elements to compare. But there are several difficulties in the way of a knowledge of the sensitivity and reaction of the liver to radiation . Perhaps the most important is the regenerative ability of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necrosis of the liver in man resulting form doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in serum enzymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The results obtained are as follow ; 1. Serum S OT activities were significantly elevated , 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation , and normalized after 4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation, and normalized after 8 weeks. 4. Histopathologic changes were focal necrosis, inflammatory cell infiltrations, loss of intracytoplasmic glycogen particles, and vacuolar degenerations of hepatocytes. It appeared marked 2 weeks after irradiation, restored after 4 weeks, and normalized after 8 weeks.

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