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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Choi, Eung-Chil (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Chung, Kyeong-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Kang, Chang-Yul (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Kim, Sook-Hee (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Kim, Jin-Sook (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Kim, You-Jin (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Lee, Kyong-Lim (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) Lee, Jong-Kil (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제5권 제1호
발행연도
1982.1
수록면
21 - 23 (3page)

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To develop new potent antitumor substancces with low toxicity from natural products, especially from higher fungi of Korea, the carpophores of some wild basidiomycetes were collected and the antitimor test for their polysaccharides was done. The dried carpophores were extracted with hot water, and from the extracts, crude polysaccharides were obtained by alcohol precipitation. The alcohol precipitated crude polysaccharides were partially purified by dialysis and then used as the samples for antitumor tests. Among tested, the polysaccharide of Laccaria laccata, Trametes sanguineus, Armlliariella mellea, Clitocybe in fundibuliformis, and Xeromphalina campanella respectively showed the inhibition ratio of 75%, 72%, 94% 55%, and 47% when administered i. p. once dailly for ten days at the dose level of 20mg/kg/day into the mice implanted with $10^{6}$ cells of sarcoma 180/mouse. However, those of Craterellus cornucopiodes, Daedaleopsis confrogosa, and Coriolus sp. showed almost no activities.

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