지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
This laboratory has recently reported the synthesis and in vitro antitumor activity of PT(II) complexes containing ethylenediamine and diphosphine. In view of the reports of others, cisplatin is toxic to the kidney since the kidney's vulnerability to PT(II) complexes may originate in its ability to accumulate and retain platinum to a greater degree than other organs. The in vitro cytotoxicity of these synthetic PT(II) complexes on the primary cultured proximal tubular cells of rabbit kidney and renal cortical cells of human kidney was investigated. Three endpoints for cytotoxicity tests were evaluated:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), $^3H$-thymidine uptake and the glucose consumption tests. The rank order of sensitivity exhibited $^3H$-thymidine uptake>MTT>glucose consumption test. The agents with diphosphine leaving group were significantly less cytotoxic than cisplatin. Moreover, 1,2-bis(diphenylphosphino)ethane (DPPE) exhibited less cytotoxicity than 1.3-bis (diphenylphosphino)propane (DPPP) against on rabbit and human cultured kidney cells. Based on these results, the decreased nephrotoxicity of these new complexes over cisplatin appeared to be partially attributable to a leaving group of DPPP and DPPE. This novel class of platinum compound represents a valuable lead in the development of a "third-generation" agent.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
1,2-디아미노프로판을 배위자로 한 백금(II) 착체의 선택적 세포독성
약학회지
1998 .01
-
1,2-비스 (디페닐포스피노)에탄을 배위자로 한 항암성백금 (II) 착체의 위암세포와 정상신장세포에 대한 선택적 세포독성
약학회지
2000 .01
-
1,3-비스페닐치오 프로판을 배위자로 한 백금 (II)착체의 선택적 세포독성
약학회지
1999 .01
-
DL-2 하이드록시 3-메틸 부틸산물 배위자로 한 새로운 항암성 백금(II) 착체의 위암세포와 정상신장세포에 대한 선택적 세포독성
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2003 .01
-
In Vitro Cytotoxicity of a Novel Platinum(II) Coordination Complex Containing Diaminocyclohexane
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2000 .01
-
항암활성을 갖는 백금 착체의 합성과 신독성
약학회지
1994 .01
-
[Pt(II)(cis-DACH) (DPPE)] .$2NO_3$: A Novel Class Of Platinum Complex Exhibiting Selective Cytotoxicity to Human Ovarian Carcinoma Cell Lines and Normal Kidney Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1997 .01
-
Cisplatin의 신장독성에 관한 연구 2. Cisplatin의 신장근위세뇨관 glucose 이동에 미치는 영향과 몇 가지 약물들의 독성경감효과 ( Studies on the Cisplatin Nephrotoxicity 2. Effects of cisplatin on the renal proximal tubular glucose transport and alleviating effects of some drugs on the renal toxicity of cisplatin )
한국환경성돌연변이·발암원학회지
1994 .03
-
In vitro antitumor activity and nephrotoxicity of a new platinum(II) complex on cancer cell-lines and normal kidney cells
대한약학회 학술대회
2001 .01
-
New platinum-complex compounds with reduced nephrotoxicity discovered in long term histoculture of human renal cortex
한국응용약물학회 춘계학술발표논문집
1995 .01
-
Selective cytotoxicity of a new platinum(II) complex on human ovarian cancer cell-lines and normal kidney cells
대한약학회 학술대회
2001 .01
-
Diaminocyclohexane을 배위자로 한 새로운 항암성 백금(II)착체류의 일반약리작용
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1998 .01
-
Effects of High Glucose Levels on the Protein Kinase C Signal Transduction Pathway in Primary Cultured Renal Proximal Tubule Cells
대한생리학회지
1996 .01
-
Effects of Human Adipose-Derived Stem Cells in Regenerating the Damaged Renal Tubular Epithelial Cells in an Animal Model of Cisplatin-Induced Acute Kidney Injury
Childhood Kidney Diseases
2015 .01
-
In vitro Antitumor Activity and Nephrotoxicity of Pt(II) Complexes Containing Diaminocyclohexane
대한약학회 학술대회
2002 .01
-
In Vitro Cytotoxic Activities of Novel Platinum(II) Complex on Gastric Cancer Cell-Lines and Normal Kidney Cells
대한약학회 학술대회
2001 .01
-
Toxicogenomics Study on Nephrotoxicants in Human Kidney Proximal Tubular (HK-2) Cells
환경독성보건학회 심포지엄 및 학술대회
2006 .05
-
Cisplatin Induces Autophagy in Human Renal Proximal Tubular Epithelial Cells
환경독성보건학회 심포지엄 및 학술대회
2014 .11
-
The Protective Effect of Ginsenosides against High Glucose-Induced Inhibition of Na⁺/glucose Cotransporter in Primary Cultured Rabbit Proximal Tubule Cells
Laboratory Animal Research
2007 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0